Biochem Biophys Res Commun 1987,
PMID: 2962579
Lin, T; Blaisdell, J; Haskell, J F
The effects of human chorionic gonadotropin (hCG) on type I insulin-like growth factor (IGF) receptors of purified Leydig cells were investigated. Sprague-Dawley rats (50 day-old) were treated with a single injection of hCG 10 units intraperitoneally, type I IGF receptors were then determined daily for 4 days. HCG caused a rapid increase in type I IGF receptors within 24 h, which returned to basal by 72 h. There was no significant change in binding affinity. Our present study indicates that type I IGF receptors of Leydig cells are up regulated by hCG, and this may be one mechanism by which hCG and IGF-I interact to enhance Leydig cell steroidogenesis.
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Text Mining Data
IGF → HCG: "
HCG caused a rapid increase in type I
IGF receptors within 24 h, which returned to basal by 72 h
"
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