Appl Biochem Biotechnol 2012,
PMID: 22052544
Nakamura, Yukio; He, Xinjun; Kato, Hiroyuki; Wakitani, Shigeyuki; Kobayashi, Tatsuya; Watanabe, Sumiko; Iida, Atsumi; Tahara, Hideaki; Warman, Matthew L; Watanapokasin, Ramida; Postlethwait, John H
MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells.
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Text Mining Data
miR-140 → Sox9: "
Using developing zebrafish, sox9a mutant ( sox9a-/- ) and sox9b mutant ( sox9b-/- ) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that
miR-140 is
regulated by the cartilage master transcription regulator
Sox9 in zebrafish and mammalian cells
"
Manually curated Databases
No curated data.