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MAPK3/MAPK1 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "
MAPK14 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "
MAPK3/MAPK1 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "
myosin II → PI3K: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K , MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "