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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining
Matrix Biol 2010, PMID: 20385232

Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.

Kim, Jinyoung; Erikson, David W; Burghardt, Robert C; Spencer, Thomas E; Wu, Guoyao; Bayless, Kayla J; Johnson, Greg A; Bazer, Fuller W

Attachment and migration of trophectoderm (Tr) cells, hallmarks of blastocyst implantation in mammals, are unique uterine events. Secreted phosphoprotein 1 (SPP1) in the uterus binds integrins on conceptus Tr and uterine luminal epithelium (LE), affecting cell-cell and cell-matrix interactions. The signal transduction pathways activated by SPP1 and integrins in conceptuses have not been elucidated. Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of: 1) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways; 2) mTOR, PI3K, MAPK3/MAPK1 (Erk1/2) and MAPK14 (p38) signaling to stimulate Tr cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells. These cell signaling pathways, acting in concert, mediate adhesion, migration and cytoskeletal remodeling of Tr cells essential for expansion and elongation of conceptuses and attachment to uterine LE for implantation.

Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System
Document information provided by NCBI PubMed

Text Mining Data

mTOR → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR , PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "

MAPK3/MAPK1 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "

MAPK14 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "

MAPK3/MAPK1 → myosin II: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K, MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "

myosin II → PI3K: " Results of this study demonstrate that SPP1 binds alphavbeta3 and alpha5beta1 integrins to induce focal adhesion assembly, a prerequisite for adhesion and migration of Tr, through activation of : 1 ) P70S6K via crosstalk between FRAP1/mTOR and MAPK pathways ; 2 ) mTOR, PI3K , MAPK3/MAPK1 ( Erk1/2 ) and MAPK14 ( p38 ) signaling to stimulate Tr cell migration ; and 3 ) focal adhesion assembly and myosin II motor activity to induce migration of Tr cells "

Manually curated Databases

No curated data.