The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009,
PMID: 19885005
Choi, Ok-Byung; Park, Joo-Hoon; Lee, Ye Jin; Lee, Chang-Kwon; Won, Kyung-Jong; Kim, Junghwan; Lee, Hwan Myung; Kim, Bokyung
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anti-cancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.
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Text Mining Data
extracellular signal regulated kinase1/2 → PDGF-BB: "
The effects of
PDGF-BB induced
extracellular signal regulated kinase1/2 was not altered by the olibanum extract
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extracellular signal regulated kinase1/2 → PDGF-BB: "
The effects of PDGF-BB induced extracellular signal regulated kinase1/2 was not altered by the olibanum extract
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