Cancer Cell 2009,
PMID: 19878869
Zhang, Yanping; Lu, Hua
Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress. In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2-mediated p53 ubiquitination and degradation, resulting in p53-dependent cell cycle arrest. By doing so, the ribosomal proteins play a crucial role in connecting deregulated cell growth with inhibition of cell division. The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomal biogenesis.
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Text Mining Data
p53 ⊣ ribosomal proteins: "
In response to this stress, several
ribosomal proteins bind to MDM2 and
block MDM2 mediated
p53 ubiquitination and degradation, resulting in p53 dependent cell cycle arrest
"
p53 → MDM2: "
In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2 mediated p53 ubiquitination and degradation, resulting in p53 dependent cell cycle arrest
"
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