J Steroid Biochem Mol Biol 2008,
PMID: 17935972
Takemori, Hiroshi; Okamoto, Mitsuhiro
Salt inducible kinase (SIK) was identified as a molecule induced in the adrenal glands of rats fed with a high-salt diet. A major downstream of SIK is regulation of camp-responsive element (CRE)-dependent gene expression. SIK represses the activity of CRE-binding protein (CREB) by phosphorylating a CREB-specific co-activator transducer of regulated CREB activity (TORC). When TORC is dephosphorylated it activates CREB in a CREB-phosphorylation independent manner. The importance of the dephosphorylation of TORC has been suggested by the fact that a kinase inhibitor staurosporine induces dephosphorylation of TORC and upregulates the gene expression of CYP11A, CYP11B1, CYP11B2 and StAR in adrenocortical cells. The identification of SIK caused a stir in the field of CREB studies and led to disclosure of cascades hidden behind the classical mechanism for CREB activity.
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Text Mining Data
CREB — salt inducible kinase: "
Regulation of
CREB mediated gene expression by
salt inducible kinase
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CRE binding protein ( CREB ) ⊣ SIK: "
SIK represses the activity of CRE binding protein ( CREB ) by phosphorylating a CREB-specific co-activator transducer of regulated CREB activity ( TORC )
"
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