J Agric Food Chem 2007,
PMID: 17929893
Han, Jong-Min; Lee, Woo Song; Kim, Ju-Ryoung; Son, Joonsok; Nam, Ki-Hoan; Choi, Seung-Chul; Lim, Jong-Seok; Jeong, Tae-Sook
Atherosclerosis is a chronic inflammatory disease that is characterized by infiltration of mononuclear lymphocytes into the intima through the expression of adhesion molecules on the arterial wall. In the present study, we report the inhibitory effects of two diarylheptanoids, 5-O-methylhirsutanonol (1) and oregonin (2), isolated from the methanolic extracts of Alnus japonica leaves, on the expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation-associated gene interleukin-1beta (IL-1beta). A further study demonstrated the inhibitory effect of compound 1 on DNA-binding of nuclear factor kappaB (NF-kappaB) and on the phosphorylation and degradation of inhibitory factor kappaBalpha (IkappaBalpha) in TNF-alpha-stimulated HUVECs. These results indicate that compounds 1 and 2 may be useful in the prevention and treatment of atherosclerosis through attenuation of adhesion molecule expression by inhibition of NF-kappaB activation.
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Text Mining Data
interleukin-1beta (IL-1beta) ⊣ tumor necrosis factor (TNF)-alpha: "
Compounds 1 and 2 inhibited
tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly
suppressed the mRNA expression of the inflammation associated gene
interleukin-1beta (IL-1beta)
"
interleukin-1beta (IL-1beta) ⊣ vascular cell adhesion molecule-1: "
Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta)
"
interleukin-1beta (IL-1beta) ⊣ intercellular adhesion molecule-1: "
Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta)
"
vascular cell adhesion molecule-1 → tumor necrosis factor (TNF)-alpha: "
Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta)
"
intercellular adhesion molecule-1 → tumor necrosis factor (TNF)-alpha: "
Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta)
"
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