Mol Cell 2007,
PMID: 17707232
Zhu, Ping; Zhou, Wenlai; Wang, Jianxun; Puc, Janusz; Ohgi, Kenneth A; Erdjument-Bromage, Hediye; Tempst, Paul; Glass, Christopher K; Rosenfeld, Michael G
Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. 2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones. Consistent with this mechanistic role, 2A-DUB participates in transcriptional regulation events in androgen receptor-dependent gene activation, and the levels of uH2A are dramatically decreased in prostate tumors, serving as a cancer-related mark. We suggest that H2A ubiquitination represents a widely used mechanism for many regulatory transcriptional programs and predict that various H2A ubiquitin ligases/deubiquitinases will be identified for specific cohorts of regulated transcription units.
Document information provided by NCBI PubMed
Text Mining Data
Dashed line = No text mining data
Manually curated Databases
-
IRef Biogrid Interaction:
MYSM1
—
TUBB1
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
RBM10
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
KIF11
—
KAT2B
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
PRMT5
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
KIF11
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
HSPA1A
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
UBC
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
EEF1A1
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
WDR77
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
KAT2B
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
HNRNPH1
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
STK38
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
HIST2H2AC
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
MYSM1
—
HIST2H2AC
(direct interaction, enzymatic study)
-
Gene Ontology Complexes PCAF complex:
PCAF complex complex (TAF12-TAF10-KAT2B-TRRAP)
-
IRef Innatedb Interaction:
HIST3H2BB
—
HIST1H1B
(unknown, -)
-
IRef Innatedb Interaction:
KIF11
—
KAT2B
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
PRMT5
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
HIST3H2BB
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
KIF11
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
HSPA1A
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
EEF1A1
(unknown, -)
-
IRef Innatedb Interaction:
HIST2H2AC
—
HIST1H1B
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
WDR77
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
KAT2B
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
HNRNPH1
(unknown, -)
-
IRef Innatedb Interaction:
MYSM1
—
HIST2H2AC
(unknown, -)
In total, 22 gene pairs are associated to this article in curated databases