Gene interactions and pathways from curated databases and text-mining
Mol Cell 2007, PMID: 17707232

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.

Zhu, Ping; Zhou, Wenlai; Wang, Jianxun; Puc, Janusz; Ohgi, Kenneth A; Erdjument-Bromage, Hediye; Tempst, Paul; Glass, Christopher K; Rosenfeld, Michael G

Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. 2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones. Consistent with this mechanistic role, 2A-DUB participates in transcriptional regulation events in androgen receptor-dependent gene activation, and the levels of uH2A are dramatically decreased in prostate tumors, serving as a cancer-related mark. We suggest that H2A ubiquitination represents a widely used mechanism for many regulatory transcriptional programs and predict that various H2A ubiquitin ligases/deubiquitinases will be identified for specific cohorts of regulated transcription units.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: MYSM1 — TUBB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — RBM10 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KIF11 — KAT2B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — PRMT5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — KIF11 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — HSPA1A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — UBC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — EEF1A1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — WDR77 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — KAT2B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — HNRNPH1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — STK38 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — HIST2H2AC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYSM1 — HIST2H2AC (direct interaction, enzymatic study)
  • Gene Ontology Complexes PCAF complex: PCAF complex complex (TAF12-TAF10-KAT2B-TRRAP)
  • IRef Innatedb Interaction: HIST3H2BB — HIST1H1B (unknown, -)
  • IRef Innatedb Interaction: KIF11 — KAT2B (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — PRMT5 (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — HIST3H2BB (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — KIF11 (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — HSPA1A (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — EEF1A1 (unknown, -)
  • IRef Innatedb Interaction: HIST2H2AC — HIST1H1B (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — WDR77 (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — KAT2B (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — HNRNPH1 (unknown, -)
  • IRef Innatedb Interaction: MYSM1 — HIST2H2AC (unknown, -)
In total, 22 gene pairs are associated to this article in curated databases