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COX-2 → EGFR: " EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells "
COX-2 — transforming growth factor-beta1: " We studied the regulation of COX-2 expression in immortalized human bronchial epithelial cells ( HBECs ) by transforming growth factor-beta1 ( TGF-beta1 ) and epidermal growth factor (EGF) because these two growth factors are present in both the pulmonary milieu of those at risk for lung cancer as well as in the tumor microenvironment "
COX-2 — epidermal growth factor (EGF): " We studied the regulation of COX-2 expression in immortalized human bronchial epithelial cells ( HBECs ) by transforming growth factor-beta1 ( TGF-beta1 ) and epidermal growth factor (EGF) because these two growth factors are present in both the pulmonary milieu of those at risk for lung cancer as well as in the tumor microenvironment "
COX-2 → TGF-beta1: " EGF significantly enhanced TGF-beta1 mediated induction of COX-2 and corresponding prostaglandin E2 ( PGE2 ) production "
COX-2 → EGF: " EGF significantly enhanced TGF-beta1 mediated induction of COX-2 and corresponding prostaglandin E2 ( PGE2 ) production "
TGF-beta1 → COX-2: " TGF-beta1 and EGF induced COX-2 at the transcriptional and post-transcriptional levels "
EGF → COX-2: " TGF-beta1 and EGF induced COX-2 at the transcriptional and post-transcriptional levels "
COX-2 → TGF-beta1: " EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or mitogen activated protein kinase kinase ( MEK ) inhibition blocked TGF-beta1 mediated COX-2 induction "
COX-2 → EGF receptor (EGFR): " EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or mitogen activated protein kinase kinase ( MEK ) inhibition blocked TGF-beta1 mediated COX-2 induction "
COX-2 → mitogen activated protein kinase kinase: " EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or mitogen activated protein kinase kinase ( MEK ) inhibition blocked TGF-beta1 mediated COX-2 induction "
EGFR → TGF-beta1: " COX-2 induction by TGF-beta1 depended upon Smad3 signaling and required the activity of EGFR or its downstream mediators "
EGFR → COX-2: " COX-2 induction by TGF-beta1 depended upon Smad3 signaling and required the activity of EGFR or its downstream mediators "
COX-2 → TGF-beta1: " COX-2 induction by TGF-beta1 depended upon Smad3 signaling and required the activity of EGFR or its downstream mediators "
COX-2 → TGF-beta1: " Autocrine amphiregulin signaling maintains EGFR in a constitutively active state in HBECs, allowing for COX-2 induction by TGF-beta1 "
COX-2 → TGF-beta1: " Thus, EGFR ligands, which are abundant in the pulmonary microenvironment of those at risk for lung cancer, potentiate and are required for COX-2 induction by TGF-beta1 in HBEC "
COX-2 ⊣ EGFR: " These findings emphasize the central role of EGFR signaling in COX-2 induction by TGF-beta1 and suggest that inhibition of EGFR signaling should be investigated further for lung cancer prevention "
COX-2 → TGF-beta1: " These findings emphasize the central role of EGFR signaling in COX-2 induction by TGF-beta1 and suggest that inhibition of EGFR signaling should be investigated further for lung cancer prevention "