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vascular endothelial growth factor → NOX3: " Insulin induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3 "
VEGF — insulin: " The aim of this study was to investigate the role of ROS producing NADPH oxidase enzymes ( NOX-es ) in insulin regulated VEGF gene activation "
insulin → VEGF: " To achieve this goal we chose HepG2 cells as our model system as these cells express the NADPH oxidase isoform NOX3 and respond to insulin stimulation with enhanced ROS production and mRNA transcription and production of VEGF "
Sp1 → MAPK: " We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha "
Sp1 → insulin: " We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha "
MAPK → HIF-1alpha: " We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha "
MAPK → insulin: " We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha "
HIF-1alpha → insulin: " We demonstrate that in control cells insulin stimulation leads to H2O2 generation, a biphasic activation of p42/44 MAPK and the induction of both Sp1 and HIF-1alpha "
VEGF-A → Sp1: " Transfection of NOX3-specific siRNA abrogates H2O2 production and inhibits exclusively the second phase of p42/44 MAPK phosphorylation and Sp1 DNA binding and thus prevents upregulation of VEGF-A mRNA expression "