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S6K1 — TRB3: " In this study, we investigated the effect of TRB3 , which acts as an endogenous inhibitor of Akt, on S6K1 activity in vitro and in vivo "
S6K1 → TRB3: " In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin, whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity "
S6K1 → mammalian target of rapamycin: " In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin , whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity "
S6K1 → insulin: " In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin, whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity "
mammalian target of rapamycin → TRB3: " In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin , whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity "
mammalian target of rapamycin → insulin: " In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin , whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity "
S6K1 → TRB3: " In C57BL/6 mice, adenoviral overexpression of TRB3 inhibited insulin stimulated activation of hepatic S6K1 "
S6K1 → insulin: " In C57BL/6 mice, adenoviral overexpression of TRB3 inhibited insulin stimulated activation of hepatic S6K1 "
S6K1 → TRB3: " In contrast, overexpression of TRB3 did not inhibit nutrient stimulated S6K1 activity "
S6K1 → insulin: " Both insulin and feeding activate S6K1 in db/db mice, but only insulin activates in the C57BL/6 strain "
Akt → insulin: " Akt was activated by insulin alone in the C57BL/6 strain and but not in db/db mice "
mammalian target of rapamycin → insulin: " Both insulin and feeding activated mammalian target of rapamycin similarly in these mice ; however, feeding was unable to activate the downstream target S6K1 in C57BL/6 mice "