Arerugi 2006,
PMID: 16671324
Inoue, Hiromasa
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play an important role in allergic asthma. These cytokines transmit signals through the JAK/STAT and the Ras/ERK signaling pathways, and SOCS family proteins and SPRED family proteins regulate these pathways. SOCS3 controls IL-12-dependent STAT4 activation and Th2 differentiation process. SPRED-1 modulates IL-5-dependent ERK activation and eosinophilia. SOCS3 and SPRED-1 may be targets for therapeutic strategies in allergic asthma.
Diseases/Pathways annotated by Medline MESH: Asthma, Respiratory Hypersensitivity
Document information provided by NCBI PubMed
Text Mining Data
STAT4 → IL-12: "
SOCS3 controls
IL-12 dependent
STAT4 activation and Th2 differentiation process
"
STAT4 — SOCS3: "
SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process
"
SOCS3 — IL-12: "
SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process
"
ERK → IL-5: "
SPRED-1 modulates IL-5 dependent ERK activation and eosinophilia
"
Manually curated Databases
No curated data.