Gene interactions and pathways from curated databases and text-mining
Arerugi 2006, PMID: 16671324

[Allergic asthma and intrinsic inhibitors of cytokine signaling].

Inoue, Hiromasa

T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play an important role in allergic asthma. These cytokines transmit signals through the JAK/STAT and the Ras/ERK signaling pathways, and SOCS family proteins and SPRED family proteins regulate these pathways. SOCS3 controls IL-12-dependent STAT4 activation and Th2 differentiation process. SPRED-1 modulates IL-5-dependent ERK activation and eosinophilia. SOCS3 and SPRED-1 may be targets for therapeutic strategies in allergic asthma.

Diseases/Pathways annotated by Medline MESH: Asthma, Respiratory Hypersensitivity
Document information provided by NCBI PubMed

Text Mining Data

STAT4 → IL-12: " SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process "

STAT4 — SOCS3: " SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process "

SOCS3 — IL-12: " SOCS3 controls IL-12 dependent STAT4 activation and Th2 differentiation process "

ERK → IL-5: " SPRED-1 modulates IL-5 dependent ERK activation and eosinophilia "

Manually curated Databases

No curated data.