Biochem Biophys Res Commun 2004,
PMID: 15240101
Sekiya, Takashi; Oda, Takeaki; Matsuura, Ken; Akiyama, Tetsu
BAMBI is a transmembrane glycoprotein related to the transforming growth factor-beta (TGF-beta)-family type I receptors and functions as a negative regulator of TGF-beta signaling during development. BAMBI is induced by BMP signaling through the evolutionary conserved BMP-responsive elements in its promoter. Furthermore, we have recently shown that Wnt/beta-catenin signaling activates transcription of BAMBI and that BAMBI expression is aberrantly elevated in most colorectal carcinomas. Here, we show that BAMBI is also directly induced by TGF-beta signaling, through the three tandem repeats of 13 bp sequences containing the SMAD-binding elements, which are distinct from the BMP-responsive element. Our findings suggest that BAMBI transcription is regulated by TGF-beta signaling through direct binding of SMAD3 and SMAD4 to the BAMBI promoter.
Diseases/Pathways annotated by Medline MESH: Hepatoblastoma, Liver Neoplasms
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Text Mining Data
BMP → BAMBI: "
BAMBI is
induced by
BMP signaling through the evolutionary conserved BMP-responsive elements in its promoter
"
BAMBI → Wnt/beta-catenin: "
Furthermore, we have recently shown that Wnt/beta-catenin signaling activates transcription of BAMBI and that BAMBI expression is aberrantly elevated in most colorectal carcinomas
"
BAMBI → Wnt/beta-catenin: "
Furthermore, we have recently shown that Wnt/beta-catenin signaling activates transcription of BAMBI and that BAMBI expression is aberrantly elevated in most colorectal carcinomas
"
Manually curated Databases
No curated data.