Gene interactions and pathways from curated databases and text-mining
Electrophoresis 2004, PMID: 15174051

An investigation into the human serum "interactome".

Zhou, Ming; Lucas, David A; Chan, King C; Issaq, Haleem J; Petricoin, Emanuel F; Liotta, Lance A; Veenstra, Timothy D; Conrads, Thomas P

The protein content of human serum is composed of a millieu of proteins from almost every type of cell and tissue within the body. The serum proteome has been shown to contain information that directly reflects pathophysiological states and represents an invaluable source of diagnostic information for a variety of different diseases. Unfortunately, the dynamic range of protein abundance, ranging from >> mg/mL level to << pg/mL level, renders complete characterization of this proteome nearly impossible with current analytical methods. To study low-abundance proteins, which have potential value for clinical diagnosis, the high-abundant species, such as immunoglobulins and albumin, are generally eliminated as the first step in many analytical protocols. This step, however, is hypothesized to concomitantly remove proteins/peptides associated with the high-abundant proteins targeted for depletion. In this study, immunoprecipitation was combined with microcapillary reversed-phase liquid chromatography (microRPLC) coupled on-line with tandem mass spectrometry (MS/MS) to investigate the low-molecular-weight proteins/peptides that associate with the most abundant species in serum. By this targeted isolation of select highly abundant serum proteins, the associated proteins/peptides can be enriched and effectively identified by microRPLC-MS/MS. Among the 210 proteins identified, 73% and 67% were not found in previous studies of the low-molecular-weight or whole-serum proteome, respectively.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: AGA — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KLK3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOA1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TTR — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ST13 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FAM169A — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — TRAPPC11 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SORBS3 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KRT6B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PPBP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CTSL — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TNS3 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ATM — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: GFAP — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SAFB2 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — AMPD3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT16 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ABCA6 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DICER1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SACS (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QC — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — GABBR1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TIAM1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SLA2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CABLES1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: JARID2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ITGB5 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — DGKG (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MOCOS — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT5 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FAM83C — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TLN2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CAMTA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CACNA1I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CDC45 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT9 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PLA2G4F — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SETX — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ITIH1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CLU — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ETF1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PDE4B — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CROT — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOA1 — SERTAD3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DERL1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PLAG1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — THRAP3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — NCOA3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CFH (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CHKB — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — APOA2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CFB — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RRP1B — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: AP4E1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SCN5A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SGOL2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SCAF1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOC3 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SETX — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — C4A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CEP44 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KRT9 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FGA — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KIAA0232 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SERPING1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: QDPR — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PDZRN4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — BBC3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PCDH1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: OR3A2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: GRAP2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RANBP2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NLRP1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CLCA2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CTAGE5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOA1 — FN1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — LDB3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CRB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT14 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IGDCC4 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — FN1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KRT10 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ITGA2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ZNF292 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOA1 — SMPDL3A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ZNF232 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — AP1M1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PDE4B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SLC1A5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: QTRTD1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PHC3 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DCC — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: GCN1L1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DCD — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NLRC4 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — LAT (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CTSL — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — TSC22D1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HBA1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CNOT1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYLK3 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — MYL4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SLC9A8 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SLC25A13 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PALB2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FAM71E2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOC1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HP — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — APOC2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — DDB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: AHSG — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TTR — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — RLF (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CP — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT16 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SPATA31A7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PF4V1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: FGA — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ZIM2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — PRSS3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — OBSL1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KCNMA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KRT6A — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PTPN5 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — TTPAL (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: OR2T6 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: LECT1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — DMD (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HBA1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — CDCP1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C1QA — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — TTN (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SPEF2 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: GJC2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: OR8D2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CST3 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOA4 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — EXOC6 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRSS1 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DNTT — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOC3 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: F2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — RANBP3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — NPHS1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CFD — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — ADRA1B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — GSN (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SPAST — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — SH3BP5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TXNDC2 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HPX — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — KRT13 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KIAA0754 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ROBO3 — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — APOA1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — F7 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RYR2 — ALB (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ALB — APOE (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: APOC1 — APOA1 (physical association, affinity chromatography technology)
  • IRef Hprd Interaction: ALB — KLK3 (in vivo)
  • IRef Hprd Interaction: ALB — ST13 (in vivo)
  • IRef Hprd Interaction: AGA — ALB (in vivo)
  • IRef Hprd Interaction: Complex of 126 proteins
  • IRef Hprd Interaction: Complex of 241 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 126 proteins
  • IRef Hprd Interaction: Complex of 16 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 157 proteins (in vivo)
  • IRef Hprd Interaction: Complex of 1090 proteins
  • IRef Hprd Interaction: Complex of 33 proteins
  • IRef Hprd Interaction: Complex of 126 proteins
  • IRef Hprd Interaction: Complex of 15499 proteins
  • IRef Hprd Interaction: F7 — ALB (in vivo)
  • IRef Hprd Interaction: RYR2 — ALB (in vivo)
  • IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 50 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 37 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 64 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 56 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 35 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation)
  • IRef Intact Interaction: Complex of 33 proteins (association, anti bait coimmunoprecipitation)
In total, 10014 gene pairs are associated to this article in curated databases