Gene interactions and pathways from curated databases and text-mining
Eur J Immunol 2003, PMID: 12672049

The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.

Nishioka, Hiroaki; Baesso, Ilenia; Semenzato, Gianpietro; Trentin, Livio; Rappuoli, Rino; Del Giudice, Giuseppe; Montecucco, Cesare

Infection by Helicobacter pylori causes an acute inflammatory response followed by a chronic infection of the human gastric mucosa characterized by the infiltration of neutrophils andmononuclear inflammatory cells. The neutrophil-activating protein of Helicobacter pylori (HP-NAP) is a virulence factor that activates neutrophils, monocytes, and mast cells. However, the mechanism by which HP-NAP activates these cells is not fully understood. Here, we show that HP-NAP induces extracellular regulated kinase (ERK) and p38-mitogen-activated protein kinase (MAPK) activation in human neutrophils; c-Jun N-terminal kinase is not activated by HP-NAP. A MAPK/ERK kinase inhibitor and a p38-MAPK inhibitor suppress HP-NAP-mediated neutrophil oxidative burst, adhesion, andchemotaxis, but not actin polymerization. Pertussis toxin (PTX) inhibits all these neutrophil functions and the MAPK activation caused by HP-NAP. These results demonstrate that HP-NAP activates neutrophils through a PTX-sensitive pathway and that ERK and p38-MAPK are involved in many neutrophil functions stimulated by HP-NAP.

Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System
Document information provided by NCBI PubMed

Text Mining Data

p38-mitogen activated protein kinase → HP-NAP: " Here, we show that HP-NAP induces extracellular regulated kinase (ERK) and p38-mitogen activated protein kinase ( MAPK ) activation in human neutrophils ; c-Jun N-terminal kinase is not activated by HP-NAP "

extracellular regulated kinase (ERK) → HP-NAP: " Here, we show that HP-NAP induces extracellular regulated kinase (ERK) and p38-mitogen activated protein kinase ( MAPK ) activation in human neutrophils ; c-Jun N-terminal kinase is not activated by HP-NAP "

p38-mitogen → HP-NAP: " Here, we show that HP-NAP induces extracellular regulated kinase (ERK) and p38-mitogen activated protein kinase ( MAPK ) activation in human neutrophils ; c-Jun N-terminal kinase is not activated by HP-NAP "

MAPK ⊣ Pertussis toxin ( PTX ): " Pertussis toxin ( PTX ) inhibits all these neutrophil functions and the MAPK activation caused by HP-NAP "

HP-NAP → p38-MAPK: " These results demonstrate that HP-NAP activates neutrophils through a PTX-sensitive pathway and that ERK and p38-MAPK are involved in many neutrophil functions stimulated by HP-NAP "

HP-NAP → ERK: " These results demonstrate that HP-NAP activates neutrophils through a PTX-sensitive pathway and that ERK and p38-MAPK are involved in many neutrophil functions stimulated by HP-NAP "

HP-NAP → p38-MAPK: " These results demonstrate that HP-NAP activates neutrophils through a PTX-sensitive pathway and that ERK and p38-MAPK are involved in many neutrophil functions stimulated by HP-NAP "

Manually curated Databases

No curated data.