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Akt → PDGF-BB: " N-Ethylmaleimide ( NEM ), a thiol alkylating agent, blocked PDGF-BB induced Akt phosphorylation without affecting its upstream phosphatidylinositol 3-kinase (PI3K) "
ribosomal protein S6 → PDGF-BB: " On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6 , 4E-BP1, and eIF4E "
eIF4E → PDGF-BB: " On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E "
4E-BP1 → PDGF-BB: " On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1 , and eIF4E "
Akt → PDGF-BB: " On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E "
p70S6K → PDGF-BB: " On the other hand, LY294002 and wortmannin, specific inhibitors of PI3K, prevented PDGF-BB induced phosphorylation of Akt and its downstream effector molecules, p70S6K , ribosomal protein S6, 4E-BP1, and eIF4E "
ribosomal protein S6 → PDGF-BB: " NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6 , 4E-BP1, and eIF4E induced by PDGF-BB , suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt "
eIF4E → PDGF-BB: " NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-BB , suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt "
4E-BP1 → PDGF-BB: " NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1 , and eIF4E induced by PDGF-BB , suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt "
p70S6K → PDGF-BB: " NEM also abrogated the phosphorylation of p70S6K , ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-BB , suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt "
FKHR-L1 → PDGF-BB: " In addition, NEM blocked PDGF-BB induced phosphorylation of BAD and forkhead transcription factor FKHR-L1 , and these events correlated with increased apoptosis "
BAD → PDGF-BB: " In addition, NEM blocked PDGF-BB induced phosphorylation of BAD and forkhead transcription factor FKHR-L1, and these events correlated with increased apoptosis "
Akt → PDGF-BB: " The inhibition of PDGF-BB induced Akt phosphorylation by NEM was completely reversed by PP2A inhibitors fostriecin and okadaic acid, ceramide synthase inhibitor fumonisin B1, and ROS scavenger N-acetylcysteine (NAC) "