Atherosclerosis 2001,
PMID: 11689202
Oh, G T; Choi, J H; Hong, J J; Kim, D Y; Lee, S B; Kim, J R; Lee, C H; Hyun, B H; Oh, S R; Bok, S H; Jeong, T S
Hematein is a compound isolated from Caesalpinia sappan that has been used in oriental medicine as both an analgesic and an anti-inflammatory agent. In this study, we examined the anti-atherogenic potential of hematein using cholesterol-fed New Zealand White (NZW) rabbits. NZW rabbits were divided into a hematein-supplemented (0.05% in diet) group (n=6), a probucol-supplemented (0.25% in diet) group (n=6), and a control group (n=6). After 8 weeks of treatments, the extent of the atherosclerotic lesions was significantly reduced in the hematein-supplemented group and the probucol-supplemented group without changing plasma lipoprotein levels. Hematein and probucol prevented the up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) expression on the descending aorta induced by cholesterol diet. In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of monocyte chemotactic protein-1 (MCP-1) respectively induced by tumor necrotic factor alpha (TNF-alpha) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell (HUVEC) culture. Also, hematein inhibited monocyte adhesion to endothelial cell and the activation of NF-kappaB in HUVECs stimulated with TNF-alpha. The results of the present study suggest that the anti-atherogenic effect of hematein is not related to control of the plasma lipid profile but probably related to the inhibition of VCAM-1 and MCP-1 expression resulting in an amelioration of lesion development in the rabbit.
Diseases/Pathways annotated by Medline MESH: Arteriosclerosis
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Text Mining Data
monocyte chemotactic protein-1 (MCP-1) → tumor necrotic factor alpha (TNF-alpha): "
In culture, hematein also significantly inhibited the secretion of soluble VCAM-1 and of
monocyte chemotactic protein-1 (MCP-1) respectively
induced by
tumor necrotic factor alpha (TNF-alpha) and mildly oxidized low density lipoprotein in human umbilical vein endothelial cell ( HUVEC ) culture
"
Manually curated Databases
No curated data.