J Immunol 2001,
PMID: 11160322
Mariner, J M; Lantz, V; Waldmann, T A; Azimi, N
IL-15 mRNA levels are increased in diseases caused by human T cell lymphotropic virus type I (HTLV-I). In this study, we demonstrated that IL-15Ralpha, the IL-15-specific binding receptor, mRNA and protein levels were also elevated in HTLV-I-infected cells. We showed that transient HTLV-I Tax expression lead to increased IL-15Ralpha mRNA levels. In addition, by using a reporter construct that bears the human IL-15Ralpha promoter, we demonstrated that Tax expression increased promoter activity by at least 4-fold. Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB-binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due, in part, to the induction of NF-kappaB. These data indicate that IL-15Ralpha is transcriptionally regulated by the HTLV-I Tax protein through the action of NF-kappaB. These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases.
Diseases/Pathways annotated by Medline MESH: Leukemia-Lymphoma, Adult T-Cell
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Text Mining Data
IL-15Ralpha → Tax: "
We showed that transient HTLV-I
Tax expression
lead to increased
IL-15Ralpha mRNA levels
"
Tax → IL-15Ralpha: "
Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due, in part, to the induction of NF-kappaB
"
Tax → NF-kappaB: "
Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due , in part, to the induction of NF-kappaB
"
IL-15Ralpha → NF-kappaB: "
Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due , in part, to the induction of NF-kappaB
"
Manually curated Databases
No curated data.