Gene interactions and pathways from curated databases and text-mining
J Immunol 2001, PMID: 11160322

Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site.

Mariner, J M; Lantz, V; Waldmann, T A; Azimi, N

IL-15 mRNA levels are increased in diseases caused by human T cell lymphotropic virus type I (HTLV-I). In this study, we demonstrated that IL-15Ralpha, the IL-15-specific binding receptor, mRNA and protein levels were also elevated in HTLV-I-infected cells. We showed that transient HTLV-I Tax expression lead to increased IL-15Ralpha mRNA levels. In addition, by using a reporter construct that bears the human IL-15Ralpha promoter, we demonstrated that Tax expression increased promoter activity by at least 4-fold. Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB-binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due, in part, to the induction of NF-kappaB. These data indicate that IL-15Ralpha is transcriptionally regulated by the HTLV-I Tax protein through the action of NF-kappaB. These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases.

Diseases/Pathways annotated by Medline MESH: Leukemia-Lymphoma, Adult T-Cell
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Text Mining Data

IL-15Ralpha → Tax: " We showed that transient HTLV-I Tax expression lead to increased IL-15Ralpha mRNA levels "

Tax → IL-15Ralpha: " Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due, in part, to the induction of NF-kappaB "

Tax → NF-kappaB: " Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due , in part, to the induction of NF-kappaB "

IL-15Ralpha → NF-kappaB: " Furthermore, using promoter deletion constructs and gel shift analysis, we defined a functional NF-kappaB binding motif in the human IL-15Ralpha promoter, suggesting that Tax activation of IL-15Ralpha is due , in part, to the induction of NF-kappaB "

Manually curated Databases

No curated data.