Redox Rep 2000,
PMID: 10939294
Piva, T J; Davern, C M; Winterford, C M; Ellem, K A
UVB-irradiated HeLa cells undergoing apoptosis have increased cell surface protease (CSP) activity compared to viable or necrotic cells. In order to elucidate whether caspase 3 plays a role in the activation of CSP in cells undergoing apoptosis, HeLa cell cultures were pre-treated with the caspase inhibitor, DEVD, prior to being exposed to 500 Jm(-2) UVB. DEVD significantly inhibited caspase 3 activity in cells undergoing apoptosis, but did not affect the activation of CSP in these cells. The findings suggest that the activation of CSP in apoptotic cells is unrelated to caspase 3 activity.
Diseases/Pathways annotated by Medline MESH: Necrosis
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Text Mining Data
CSP — caspase: "
In order to elucidate whether
caspase 3
plays a role in the activation of
CSP in cells undergoing apoptosis, HeLa cell cultures were pre treated with the caspase inhibitor, DEVD, prior to being exposed to 500 Jm ( -2 ) UVB
"
Manually curated Databases
No curated data.