Proc Natl Acad Sci U S A 2000,
PMID: 10908663
Shu, H B; Johnson, H
TALL-1 is a recently identified member of the tumor necrosis factor (TNF) family that costimulates B lymphocyte proliferation. Here we show that B cell maturation protein (BCMA), a member of the TNF receptor family that is expressed only by B lymphocytes, specifically binds to TALL-1. A soluble receptor containing the extracellular domain of BCMA blocks the binding of TALL-1 to its receptor on the plasma membrane and inhibits TALL-1-triggered B lymphocyte costimulation. Overexpression of BCMA activates NF-kappaB, and this activation is potentiated by TALL-1. Moreover, BCMA-mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kappaB-inducing kinase (NIK), and IkappaB kinase (IKK). These data indicate that BCMA is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases.
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Text Mining Data
NF-kappaB ⊣ BCMA: "
Overexpression of
BCMA activates
NF-kappaB , and this activation is potentiated by TALL-1
"
NF-kappaB → TALL-1: "
Overexpression of BCMA activates NF-kappaB , and this activation is potentiated by TALL-1
"
NF-kappaB ⊣ TNF receptor associated factor 5 (TRAF5): "
Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5) , TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK)
"
NF-kappaB ⊣ TRAF6: "
Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6 , NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK)
"
NF-kappaB ⊣ IkappaB kinase (IKK): "
Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK)
"
NF-kappaB → BCMA: "
Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK)
"
Manually curated Databases
-
IRef Biogrid Interaction:
TNFSF13B
—
TNFRSF17
(physical association, affinity chromatography technology)
-
IRef Hprd Interaction:
TNFSF13B
—
TNFRSF17
(in vitro)
-
IRef Hprd Interaction:
TNFSF13B
—
TNFRSF17
(in vivo)
In total, 1 gene pairs are associated to this article in curated databases