Gene interactions and pathways from curated databases and text-mining
Proc Natl Acad Sci U S A 2000, PMID: 10908663

B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.

Shu, H B; Johnson, H

TALL-1 is a recently identified member of the tumor necrosis factor (TNF) family that costimulates B lymphocyte proliferation. Here we show that B cell maturation protein (BCMA), a member of the TNF receptor family that is expressed only by B lymphocytes, specifically binds to TALL-1. A soluble receptor containing the extracellular domain of BCMA blocks the binding of TALL-1 to its receptor on the plasma membrane and inhibits TALL-1-triggered B lymphocyte costimulation. Overexpression of BCMA activates NF-kappaB, and this activation is potentiated by TALL-1. Moreover, BCMA-mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kappaB-inducing kinase (NIK), and IkappaB kinase (IKK). These data indicate that BCMA is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases.

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Text Mining Data

NF-kappaB ⊣ BCMA: " Overexpression of BCMA activates NF-kappaB , and this activation is potentiated by TALL-1 "

NF-kappaB → TALL-1: " Overexpression of BCMA activates NF-kappaB , and this activation is potentiated by TALL-1 "

NF-kappaB ⊣ TNF receptor associated factor 5 (TRAF5): " Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5) , TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK) "

NF-kappaB ⊣ TRAF6: " Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6 , NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK) "

NF-kappaB ⊣ IkappaB kinase (IKK): " Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK) "

NF-kappaB → BCMA: " Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6, NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK) "

Manually curated Databases

  • IRef Biogrid Interaction: TNFSF13B — TNFRSF17 (physical association, affinity chromatography technology)
  • IRef Hprd Interaction: TNFSF13B — TNFRSF17 (in vitro)
  • IRef Hprd Interaction: TNFSF13B — TNFRSF17 (in vivo)
In total, 1 gene pairs are associated to this article in curated databases