Gene interactions and pathways from curated databases and text-mining
FEBS Lett 1999, PMID: 10580107

Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.

Kumar, A; Dhawan, S; Mukhopadhyay, A; Aggarwal, B B

We have previously shown that human immunodeficiency virus (HIV)-1-tat induces the production of matrix metalloproteinase-9 (MMP-9) in human monocytes by a mechanism that is not understood. In the present report, we demonstrate that HIV-tat-induced expression of MMP-9 is blocked by inhibitors of protein tyrosine phosphatases (PTPases). PTPase inhibitors also blocked HIV-tat-induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction. These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB.

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Text Mining Data

matrix metalloproteinase-9 (MMP-9) → -1-tat: " We have previously shown that human immunodeficiency virus ( HIV ) -1-tat induces the production of matrix metalloproteinase-9 (MMP-9) in human monocytes by a mechanism that is not understood "

MMP-9 → HIV-tat: " In the present report, we demonstrate that HIV-tat induced expression of MMP-9 is blocked by inhibitors of protein tyrosine phosphatases ( PTPases ) "

transcription factor → HIV-tat: " PTPase inhibitors also blocked HIV-tat induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction "

NF-kappaB → HIV-tat: " PTPase inhibitors also blocked HIV-tat induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction "

IkappaBalpha → HIV-tat: " PTPase inhibitors also blocked HIV-tat induced nuclear transcription factor NF-kappaB activation and IkappaBalpha degradation required for MMP-9 induction "

HIV-tat → MMP-9: " These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB "

NF-kappaB → HIV-tat: " These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB "

NF-kappaB → MMP-9: " These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB "

Manually curated Databases

No curated data.