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IKB-kinase (IKK) → NF-kappaB: " Activation of the nuclear transcription factor NF-kappaB by inflammatory cytokines requires the successive action of NF-kappaB inducing kinase (NIK) and an IKB-kinase (IKK) complex composed of IKKalpha and IKKbeta "
tumour necrosis factor (TNF) → serine-threonine kinase: " Here we show that the Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour necrosis factor (TNF) "
tumour necrosis factor (TNF) → NF-kappaB: " Here we show that the Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour necrosis factor (TNF) "
NF-kappaB → serine-threonine kinase: " Here we show that the Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour necrosis factor (TNF) "
Akt → TNF: " TNF activates phosphatidylinositol-3-OH kinase ( PI(3)K ) and its downstream target Akt ( protein kinase B ) "
NF-kappaB ⊣ Akt: " Wortmannin ( a PI(3)K inhibitor ), dominant negative PI(3)K or kinase-dead Akt inhibits TNF mediated NF-kappaB activation "
NF-kappaB ⊣ PI(3)K: " Wortmannin ( a PI(3)K inhibitor ), dominant negative PI(3)K or kinase-dead Akt inhibits TNF mediated NF-kappaB activation "
PI(3)K ⊣ Akt: " Wortmannin ( a PI(3)K inhibitor ), dominant negative PI(3)K or kinase-dead Akt inhibits TNF mediated NF-kappaB activation "
NF-kappaB → TNF: " Wortmannin ( a PI(3)K inhibitor ), dominant negative PI(3)K or kinase-dead Akt inhibits TNF mediated NF-kappaB activation "
NF-kappaB → Akt: " Constitutively active Akt induces NF-kappaB activity and this effect is blocked by dominant negative NIK "
NF-kappaB ⊣ Akt: " Conversely, NIK activates NF-kappaB and this is blocked by kinase-dead Akt "
TNF → Akt: " Thus, both Akt and NIK are necessary for TNF activation of NF-kappaB "
TNF → NF-kappaB: " Thus, both Akt and NIK are necessary for TNF activation of NF-kappaB "
NF-kappaB → Akt: " Thus, both Akt and NIK are necessary for TNF activation of NF-kappaB "
IKKalpha → Akt: " Akt mediates IKKalpha phosphorylation at threonine 23 "
TNF → NF-kappaB: " Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB "
Akt → NF-kappaB: " Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB "