Mouse Gene Wnt11 (ENSMUST00000167303.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus wingless-type MMTV integration site family, member 11 (Wnt11), transcript variant 2, mRNA. (from RefSeq NM_009519)
Gencode Transcript: ENSMUST00000167303.7
Gencode Gene: ENSMUSG00000015957.12
Transcript (Including UTRs)
   Position: mm10 chr7:98,838,845-98,853,751 Size: 14,907 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr7:98,839,108-98,853,287 Size: 14,180 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:98,838,845-98,853,751)mRNA (may differ from genome)Protein (354 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q059Y4_MOUSE
DESCRIPTION: RecName: Full=Protein Wnt;
FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
SIMILARITY: Belongs to the Wnt family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.20263-0.480 Picture PostScript Text
3' UTR -173.20464-0.373 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005817 - Wnt
IPR026536 - Wnt-11
IPR018161 - Wnt_CS

Pfam Domains:
PF00110 - wnt family

ModBase Predicted Comparative 3D Structure on Q059Y4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity
GO:0005102 receptor binding
GO:0030295 protein kinase activator activity
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007275 multicellular organism development
GO:0010628 positive regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0031667 response to nutrient levels
GO:0032147 activation of protein kinase activity
GO:0034394 protein localization to cell surface
GO:0043066 negative regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048706 embryonic skeletal system development
GO:0051496 positive regulation of stress fiber assembly
GO:0060197 cloacal septation
GO:0060484 lung-associated mesenchyme development
GO:0060548 negative regulation of cell death
GO:0060675 ureteric bud morphogenesis
GO:0061101 neuroendocrine cell differentiation
GO:0072177 mesonephric duct development
GO:0090037 positive regulation of protein kinase C signaling
GO:0090090 negative regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK138967 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530032K24 product:wingless-related MMTV integration site 11, full insert sequence.
AK077828 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930404H12 product:WNT-11 PROTEIN PRECURSOR homolog [Mus musculus], full insert sequence.
X70800 - M.musculus wnt-11 mRNA.
BC125482 - Mus musculus wingless-related MMTV integration site 11, mRNA (cDNA clone MGC:159185 IMAGE:40129997), complete cds.
BC125484 - Mus musculus wingless-related MMTV integration site 11, mRNA (cDNA clone MGC:159187 IMAGE:40129999), complete cds.
BC144947 - Mus musculus cDNA clone IMAGE:9053495.
AK031573 - Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030455A19 product:WNT-11 PROTEIN PRECURSOR, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04310 - Wnt signaling pathway
mmu04340 - Hedgehog signaling pathway
mmu04916 - Melanogenesis
mmu05200 - Pathways in cancer
mmu05217 - Basal cell carcinoma

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_19091, NM_009519, Q059Y4, Q059Y4_MOUSE, uc009ikx.1, uc009ikx.2, uc009ikx.3
UCSC ID: uc009ikx.3
RefSeq Accession: NM_009519
Protein: Q059Y4 CCDS: CCDS21475.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.