Mouse Gene Pak1 (ENSMUST00000033040.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus p21 (RAC1) activated kinase 1 (Pak1), transcript variant 1, mRNA. (from RefSeq NM_011035)
Gencode Transcript: ENSMUST00000033040.11
Gencode Gene: ENSMUSG00000030774.13
Transcript (Including UTRs)
Position: mm10 chr7:97,842,935-97,912,381 Size: 69,447 Total Exon Count: 15 Strand: +
Coding Region
Position: mm10 chr7:97,854,460-97,911,182 Size: 56,723 Coding Exon Count: 14
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: G5E884_MOUSE
DESCRIPTION: SubName: Full=Serine/threonine-protein kinase PAK 1; SubName: Full=p21 (CDKN1A)-activated kinase 1, isoform CRA_b;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SIMILARITY: Contains 1 CRIB domain.SIMILARITY: Contains 1 protein kinase domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011009 - Kinase-like_dom
IPR000095 - PAK_box_Rho-bd
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS
Pfam Domains: PF00069 - Protein kinase domain
PF00786 - P21-Rho-binding domain
PF07714 - Protein tyrosine kinase
SCOP Domains: 47912 - Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on G5E884
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF196446 - JP 2014500723-A/3949: Polycomb-Associated Non-Coding RNAs.BC055740 - Mus musculus p21 (CDKN1A)-activated kinase 1, mRNA (cDNA clone IMAGE:6810707), containing frame-shift errors.BC060157 - Mus musculus p21 (CDKN1A)-activated kinase 1, mRNA (cDNA clone IMAGE:6810707).LF204629 - JP 2014500723-A/12132: Polycomb-Associated Non-Coding RNAs.BC079838 - Mus musculus cDNA clone IMAGE:6812253, containing frame-shift errors.AF082077 - Mus musculus Cdc42/Rac effector kinase PAK-A (Paka) mRNA, complete cds.AK077497 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730422C08 product:p21 (CDKN1A)-activated kinase 1, full insert sequence.BC145698 - Mus musculus cDNA clone IMAGE:40131001.BC167167 - Synthetic construct Mus musculus clone IMAGE:100068067, MGC:195684 p21 (CDKN1A)-activated kinase 1 (Pak1) mRNA, encodes complete protein.MA432023 - JP 2018138019-A/3949: Polycomb-Associated Non-Coding RNAs.MA440206 - JP 2018138019-A/12132: Polycomb-Associated Non-Coding RNAs.AK078711 - Mus musculus adult male eyeball cDNA, RIKEN full-length enriched library, clone:7530419B14 product:unclassifiable, full insert sequence.LF294396 - JP 2014500723-A/101899: Polycomb-Associated Non-Coding RNAs.LF294397 - JP 2014500723-A/101900: Polycomb-Associated Non-Coding RNAs.LF294401 - JP 2014500723-A/101904: Polycomb-Associated Non-Coding RNAs.LF294408 - JP 2014500723-A/101911: Polycomb-Associated Non-Coding RNAs.LF294416 - JP 2014500723-A/101919: Polycomb-Associated Non-Coding RNAs.MA529973 - JP 2018138019-A/101899: Polycomb-Associated Non-Coding RNAs.MA529974 - JP 2018138019-A/101900: Polycomb-Associated Non-Coding RNAs.MA529978 - JP 2018138019-A/101904: Polycomb-Associated Non-Coding RNAs.MA529985 - JP 2018138019-A/101911: Polycomb-Associated Non-Coding RNAs.MA529993 - JP 2018138019-A/101919: Polycomb-Associated Non-Coding RNAs.LF294418 - JP 2014500723-A/101921: Polycomb-Associated Non-Coding RNAs.MA529995 - JP 2018138019-A/101921: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: G5E884, G5E884_MOUSE, mCG_7049, NM_011035, uc009ijv.1, uc009ijv.2UCSC ID: uc009ijv.2RefSeq Accession: NM_011035
Protein: G5E884
CCDS: CCDS21464.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.