Mouse Gene Eif5 (ENSMUST00000050993.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Eif5 (from geneSymbol)
Gencode Transcript: ENSMUST00000050993.10
Gencode Gene: ENSMUSG00000021282.17
Transcript (Including UTRs)
   Position: mm10 chr12:111,538,782-111,544,923 Size: 6,142 Total Exon Count: 11 Strand: +
Coding Region
   Position: mm10 chr12:111,539,616-111,544,618 Size: 5,003 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:111,538,782-111,544,923)mRNA (may differ from genome)Protein (429 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.70374-0.357 Picture PostScript Text
3' UTR -57.90305-0.190 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR016021 - MIF4-like_typ_1/2/3
IPR002735 - Transl_init_fac_IF2/IF5
IPR016189 - Transl_init_fac_IF2/IF5_N
IPR016190 - Transl_init_fac_IF2/IF5_Zn-bd
IPR003307 - W2_domain

Pfam Domains:
PF01873 - Domain found in IF2B/IF5
PF02020 - eIF4-gamma/eIF5/eIF2-epsilon

SCOP Domains:
48371 - ARM repeat
100966 - Translation initiation factor 2 beta, aIF2beta, N-terminal domain
75689 - Zinc-binding domain of translation initiation factor 2 beta

ModBase Predicted Comparative 3D Structure on Q3TQR3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003743 translation initiation factor activity
GO:0071074 eukaryotic initiation factor eIF2 binding

Biological Process:
GO:0001731 formation of translation preinitiation complex
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0090630 activation of GTPase activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC025557 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone MGC:38162 IMAGE:5321771), complete cds.
BC039275 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone MGC:36374 IMAGE:4984912), complete cds.
AK159232 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420011C22 product:eukaryotic translation initiation factor 5, full insert sequence.
AK076403 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732496K05 product:EUKARYOTIC TRANSLATION INITIATION FACTOR 5 (EIF-5) homolog [Rattus norvegicus], full insert sequence.
AK172048 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830033B03 product:eukaryotic translation initiation factor 5, full insert sequence.
AK163368 - Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020023P12 product:eukaryotic translation initiation factor 5, full insert sequence.
BC023074 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5358318), partial cds.
AK167331 - Mus musculus 12 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530005F20 product:eukaryotic translation initiation factor 5, full insert sequence.
AK160828 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:3426401C09 product:eukaryotic translation initiation factor 5, full insert sequence.
BC042622 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5368099).
AK166775 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0011F19 product:eukaryotic translation initiation factor 5, full insert sequence.
BC023169 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:4951048), partial cds.
AK161554 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330406H02 product:eukaryotic translation initiation factor 5, full insert sequence.
AK160879 - Mus musculus 12 days embryo embryonic body below diaphragm region cDNA, RIKEN full-length enriched library, clone:3732405H24 product:eukaryotic translation initiation factor 5, full insert sequence.
BC029003 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5356723), partial cds.
BC056633 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5037773), partial cds.
BC019769 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5135983), partial cds.
BC012220 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:4024934), with apparent retained intron.
AK051980 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230030G14 product:unclassifiable, full insert sequence.
BC025523 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:5323163), partial cds.
AK212690 - Mus musculus cDNA, clone:Y2G0125M16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000055218, based on BLAT search.
AK182296 - Mus musculus cDNA, clone:Y0G0121I01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001308, based on BLAT search.
AK216620 - Mus musculus cDNA, clone:Y2G0138P12, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001308, based on BLAT search.
BC029628 - Mus musculus eukaryotic translation initiation factor 5, mRNA (cDNA clone IMAGE:3483440), partial cds.
AK218038 - Mus musculus cDNA, clone:Y2G0143M22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001308, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu03013 - RNA transport

BioCarta from NCI Cancer Genome Anatomy Project
m_eif2Pathway - Regulation of eIF2
m_eifPathway - Eukaryotic protein translation

-  Other Names for This Gene
  Alternate Gene Symbols: AK167331, mCG_118037, mCG_119306, Q3TQR3, Q3TQR3_MOUSE, uc007pdg.1, uc007pdg.2, uc007pdg.3
UCSC ID: uc007pdg.3
RefSeq Accession: NM_173363
Protein: Q3TQR3 CCDS: CCDS26180.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.