Mouse Gene Pex3 (ENSMUST00000019945.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus peroxisomal biogenesis factor 3 (Pex3), transcript variant 1, mRNA. (from RefSeq NM_019961)
Gencode Transcript: ENSMUST00000019945.14
Gencode Gene: ENSMUSG00000019809.16
Transcript (Including UTRs)
   Position: mm10 chr10:13,524,116-13,553,139 Size: 29,024 Total Exon Count: 12 Strand: -
Coding Region
   Position: mm10 chr10:13,524,885-13,552,898 Size: 28,014 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:13,524,116-13,553,139)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PEX3_MOUSE
DESCRIPTION: RecName: Full=Peroxisomal biogenesis factor 3; AltName: Full=Peroxin-3; AltName: Full=Peroxisomal assembly protein PEX3;
FUNCTION: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
SUBUNIT: Interacts with PEX19 (By similarity).
SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Identified in all tissues analyzed, with the strongest expression in liver and in testis.
SIMILARITY: Belongs to the peroxin-3 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.50241-0.380 Picture PostScript Text
3' UTR -166.60769-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006966 - Peroxin-3

Pfam Domains:
PF04882 - Peroxin-3

ModBase Predicted Comparative 3D Structure on Q9QXY9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0007031 peroxisome organization
GO:0016557 peroxisome membrane biogenesis
GO:0045046 protein import into peroxisome membrane

Cellular Component:
GO:0005654 nucleoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex
GO:0032994 protein-lipid complex


-  Descriptions from all associated GenBank mRNAs
  AK005978 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700014F15 product:peroxisomal biogenesis factor 3, full insert sequence.
AK013522 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900010N04 product:peroxisomal biogenesis factor 3, full insert sequence.
BC033415 - Mus musculus peroxisomal biogenesis factor 3, mRNA (cDNA clone MGC:32215 IMAGE:5008068), complete cds.
BC037606 - Mus musculus peroxisomal biogenesis factor 3, mRNA (cDNA clone MGC:46840 IMAGE:5361347), complete cds.
AF152996 - Mus musculus peroxisomal assembly protein PEX3 mRNA, complete cds.
AK146934 - Mus musculus 17 days embryo heart cDNA, RIKEN full-length enriched library, clone:I920076M02 product:peroxisomal biogenesis factor 3, full insert sequence.
AK005315 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500031G23 product:peroxisomal biogenesis factor 3, full insert sequence.
AK012827 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810027F19 product:peroxisomal biogenesis factor 3, full insert sequence.
AK075820 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010109M11 product:peroxisomal biogenesis factor 3, full insert sequence.
AK083778 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130007G21 product:peroxisomal biogenesis factor 3, full insert sequence.
AK186968 - Mus musculus cDNA, clone:Y0G0139G02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019945, based on BLAT search.
AK050562 - Mus musculus adult pancreas islet cells cDNA, RIKEN full-length enriched library, clone:C820018L10 product:peroxisomal biogenesis factor 3, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04146 - Peroxisome

Reactome (by CSHL, EBI, and GO)

Protein Q9QXY9 (Reactome details) participates in the following event(s):

R-MMU-382613 PEX-19 docks ABCD1/D2/D3 to peroximal membrane
R-MMU-1369062 ABC transporters in lipid homeostasis
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: NM_019961, PEX3_MOUSE, Q9QXY9, uc007eky.1, uc007eky.2, uc007eky.3
UCSC ID: uc007eky.3
RefSeq Accession: NM_019961
Protein: Q9QXY9 (aka PEX3_MOUSE)
CCDS: CCDS23702.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.