Mouse Gene Pomc (ENSMUST00000020990.7) from GENCODE VM33
Description: Mus musculus pro-opiomelanocortin-alpha (Pomc), transcript variant 4, mRNA. (from RefSeq NM_008895) RefSeq Summary (NM_008895): This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Gencode Transcript: ENSMUST00000020990.7 Gencode Gene: ENSMUSG00000020660.7 Transcript (Including UTRs) Position: mm39 chr12:4,004,951-4,010,642 Size: 5,692 Total Exon Count: 3 Strand: + Coding Region Position: mm39 chr12:4,008,129-4,010,468 Size: 2,340 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01193
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006091 generation of precursor metabolites and energy GO:0007165 signal transduction GO:0007218 neuropeptide signaling pathway GO:0007267 cell-cell signaling GO:0008217 regulation of blood pressure GO:0010469 regulation of receptor activity GO:0032098 regulation of appetite GO:0032720 negative regulation of tumor necrosis factor production GO:0033059 cellular pigmentation GO:0042593 glucose homeostasis GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0070873 regulation of glycogen metabolic process GO:2000852 regulation of corticosterone secretion
US Server
