Human Gene DACH1 (ENST00000613252.5) from GENCODE V44
Description: Homo sapiens dachshund family transcription factor 1 (DACH1), transcript variant 2, mRNA. (from RefSeq NM_080760) RefSeq Summary (NM_080759): This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000613252.5 Gencode Gene: ENSG00000276644.5 Transcript (Including UTRs) Position: hg38 chr13:71,437,966-71,867,204 Size: 429,239 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr13:71,440,655-71,866,769 Size: 426,115 Coding Exon Count: 11
ID:DACH1_HUMAN DESCRIPTION: RecName: Full=Dachshund homolog 1; Short=Dach1; FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). SUBUNIT: Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4. INTERACTION: O75376:NCOR1; NbExp=2; IntAct=EBI-347111, EBI-347233; Q13485:SMAD4; NbExp=3; IntAct=EBI-347111, EBI-347263; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen. DOMAIN: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain. SIMILARITY: Belongs to the DACH/dachshund family. SEQUENCE CAUTION: Sequence=CAA06666.1; Type=Erroneous initiation; Sequence=CAC12840.2; Type=Erroneous gene model prediction; Sequence=CAH73005.1; Type=Erroneous gene model prediction; Sequence=CAH73006.1; Type=Erroneous gene model prediction; Sequence=CAH73303.1; Type=Erroneous gene model prediction; Sequence=CAH73304.1; Type=Erroneous gene model prediction; Sequence=CAI14979.1; Type=Erroneous gene model prediction; Sequence=CAI14980.1; Type=Erroneous gene model prediction; Sequence=CAI16673.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DACH1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UI36
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001967 suckling behavior GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007585 respiratory gaseous exchange GO:0008283 cell proliferation GO:0010944 negative regulation of transcription by competitive promoter binding GO:0030336 negative regulation of cell migration GO:0033262 regulation of nuclear cell cycle DNA replication GO:0045892 negative regulation of transcription, DNA-templated GO:0046545 development of primary female sexual characteristics GO:0048147 negative regulation of fibroblast proliferation GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0060244 negative regulation of cell proliferation involved in contact inhibition GO:2000279 negative regulation of DNA biosynthetic process
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