S. cerevisiae Gene HIS1 (YER055C)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: HIS1_YEAST
DESCRIPTION: RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRT; Short=ATP-PRTase; EC=2.4.2.17;
FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity). CATALYTIC ACTIVITY: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the ATP phosphoribosyltransferase family.
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Primer design for this transcript
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR013820 - ATP_PRibTrfase_cat
IPR018198 - ATP_PRibTrfase_CS
IPR001348 - ATP_PRibTrfase_HisG
IPR020621 - ATP_PRibTrfase_HisG_long
IPR013115 - HisG_C
IPR011322 - N-reg_PII-like_a/b
IPR015867 - N-reg_PII/ATP_PRibTrfase_C
Pfam Domains: PF01634 - ATP phosphoribosyltransferase
PF08029 - HisG, C-terminal domain
ModBase Predicted Comparative 3D Structure on P00498
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Human | Mouse | Rat | Zebrafish | D. melanogaster | C. elegans |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Other Names for This Gene
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UCSC ID: YER055C Protein: P00498
(aka HIS1_YEAST)
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SGD Genes Methods, Credits, and Data Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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