S. cerevisiae Gene HIS1 (YER055C)
  Description: ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts transcription is regulated by general amino acid control
Transcript (Including UTRs)
   Position: sacCer3 chrV:264,892-265,785 Size: 894 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrV:264,892-265,785 Size: 894 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersProtein StructureOther Species
GO AnnotationsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrV:264,892-265,785)mRNAProtein (297 aa)
Gene SorterGenome BrowserOther Species FASTAAlphaFoldSGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: HIS1_YEAST
DESCRIPTION: RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRT; Short=ATP-PRTase; EC=2.4.2.17;
FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).
CATALYTIC ACTIVITY: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the ATP phosphoribosyltransferase family.

-  Primer design for this transcript
 

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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013820 - ATP_PRibTrfase_cat
IPR018198 - ATP_PRibTrfase_CS
IPR001348 - ATP_PRibTrfase_HisG
IPR020621 - ATP_PRibTrfase_HisG_long
IPR013115 - HisG_C
IPR011322 - N-reg_PII-like_a/b
IPR015867 - N-reg_PII/ATP_PRibTrfase_C

Pfam Domains:
PF01634 - ATP phosphoribosyltransferase
PF08029 - HisG, C-terminal domain

ModBase Predicted Comparative 3D Structure on P00498
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003879 ATP phosphoribosyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0000105 histidine biosynthetic process
GO:0008652 cellular amino acid biosynthetic process

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm


-  Other Names for This Gene
  UCSC ID: YER055C
Protein: P00498 (aka HIS1_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.