S. cerevisiae Gene HIS7 (YBR248C)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: HIS5_YEAST
DESCRIPTION: RecName: Full=Imidazole glycerol phosphate synthase hisHF; Short=IGP synthase; Short=IGPS; Short=ImGP synthase; Includes: RecName: Full=Glutamine amidotransferase; EC=2.4.2.-; Includes: RecName: Full=Cyclase; EC=4.1.3.-;
FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR. CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. SUBUNIT: Monomer. INDUCTION: By amino acid starvation. It has a GCN4-dependent and a GCN4-independent (basal) expression. MISCELLANEOUS: Present with 11800 molecules/cell in log phase SD medium. SIMILARITY: In the C-terminal section; belongs to the HisA/HisF family. SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.
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Primer design for this transcript
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR013785 - Aldolase_TIM
IPR017926 - GATASE_1
IPR006062 - His_biosynth
IPR004651 - HisF
IPR014640 - IGPS_HisHF
IPR010139 - Imidazole-glycPsynth_HisH
IPR011060 - RibuloseP-bd_barrel
Pfam Domains: PF00117 - Glutamine amidotransferase class-I
PF00977 - Histidine biosynthesis protein
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P33734
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Human | Mouse | Rat | Zebrafish | D. melanogaster | C. elegans |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Other Names for This Gene
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UCSC ID: YBR248C Protein: P33734
(aka HIS5_YEAST)
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SGD Genes Methods, Credits, and Data Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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