ID:UBP11_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 11; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 11; AltName: Full=Ubiquitin thioesterase 11; AltName: Full=Ubiquitin-specific-processing protease 11; FUNCTION: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Interacts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA. Interacts with papilloma virus protein 16E7. INTERACTION: P03129:E7 (xeno); NbExp=6; IntAct=EBI-306876, EBI-866453; P04608:tat (xeno); NbExp=3; IntAct=EBI-306876, EBI-6164389; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin. SIMILARITY: Belongs to the peptidase C19 family. SIMILARITY: Contains 1 DUSP domain. CAUTION: It is uncertain whether Met-1 or Met-44 is the initiator. SEQUENCE CAUTION: Sequence=AAC50450.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC50450.1; Type=Frameshift; Positions=65, 117, 134, 146; Sequence=BAC20463.1; Type=Erroneous initiation; Sequence=CAD20056.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51784
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC140849 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone MGC:176526 IMAGE:9021717), complete cds. KJ892481 - Synthetic construct Homo sapiens clone ccsbBroadEn_01875 USP11 gene, encodes complete protein. AK055588 - Homo sapiens cDNA FLJ31026 fis, clone HLUNG2000549, highly similar to Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15). AK098394 - Homo sapiens cDNA FLJ25528 fis, clone CBR07442, highly similar to UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11 (EC 3.1.2.15). BC073960 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:6182961), with apparent retained intron. BC063668 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:4180680), partial cds. AB073597 - Homo sapiens usp11 mRNA for deubiquitinating enzyme, complete cds. BC000350 - Homo sapiens ubiquitin specific peptidase 11, mRNA (cDNA clone IMAGE:2961383), partial cds. AB385092 - Synthetic construct DNA, clone: pF1KB5390, Homo sapiens USP11 gene for ubiquitin carboxyl-terminal hydrolase 11, complete cds, without stop codon, in Flexi system. JD027528 - Sequence 8552 from Patent EP1572962. JD035719 - Sequence 16743 from Patent EP1572962. U44839 - Human putative ubiquitin C-terminal hydrolase (UHX1) mRNA, complete cds. AK294635 - Homo sapiens cDNA FLJ61237 complete cds, highly similar to Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.1.2.15). JD166067 - Sequence 147091 from Patent EP1572962. JD023991 - Sequence 5015 from Patent EP1572962. JD435656 - Sequence 416680 from Patent EP1572962. AK092258 - Homo sapiens cDNA FLJ34939 fis, clone NT2RP7006619, highly similar to UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11 (EC 3.1.2.15). DQ581100 - Homo sapiens piRNA piR-49212, complete sequence. JD310235 - Sequence 291259 from Patent EP1572962. JD455362 - Sequence 436386 from Patent EP1572962. JD092149 - Sequence 73173 from Patent EP1572962. JD282142 - Sequence 263166 from Patent EP1572962. JD068899 - Sequence 49923 from Patent EP1572962. JD394018 - Sequence 375042 from Patent EP1572962. JD489273 - Sequence 470297 from Patent EP1572962. JD429812 - Sequence 410836 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P51784 (Reactome details) participates in the following event(s):
R-HSA-6781897 USP11 deubiquitinates NFKBIA R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-5689880 Ub-specific processing proteases R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-5688426 Deubiquitination R-HSA-390466 Chaperonin-mediated protein folding R-HSA-597592 Post-translational protein modification R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
