ID:TRAD1_HUMAN DESCRIPTION: RecName: Full=TRAF-type zinc finger domain-containing protein 1; AltName: Full=Protein FLN29; FUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). SUBUNIT: Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 (By similarity). Interacts with TRAF6. SIMILARITY: Contains 1 TRAF-type zinc finger.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TRAFD1 CDC HuGE Published Literature: TRAFD1 Positive Disease Associations: hemoglobin
, type 1 diabetes Related Studies:
hemoglobin Ganesh ,et al. 2009, Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium, Nature genetics 2009 41- 11 : 1191-8.
[PubMed 19862010]
type 1 diabetes WTCCC ,et al. 2007, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls, Nature 2007 447- 7145 : 661-78.
[PubMed 17554300]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14545
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.