ID:TM219_HUMAN DESCRIPTION: RecName: Full=Insulin-like growth factor-binding protein 3 receptor; Short=IGFBP-3R; AltName: Full=Transmembrane protein 219; Flags: Precursor; FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. SUBUNIT: Interacts with IGFBP3. Interacts with CASP8. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in normal tissues but suppressed in prostate and breast tumor.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86XT9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
