Human Gene TMEM105 (uc002kad.2)
  Description: Homo sapiens transmembrane protein 105 (TMEM105), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:79,285,072-79,304,474 Size: 19,403 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr17:79,287,451-79,288,262 Size: 812 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:79,285,072-79,304,474)mRNA (may differ from genome)Protein (129 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtPubMed
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TM105_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 105;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM105
CDC HuGE Published Literature: TMEM105
Positive Disease Associations: Stroke
Related Studies:
  1. Stroke
    , , . [PubMed 0]

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.74 RPKM in Liver
Total median expression: 3.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -253.10550-0.460 Picture PostScript Text
3' UTR -1044.002379-0.439 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8N8V8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK096111 - Homo sapiens cDNA FLJ38792 fis, clone LIVER2003511.
JD253053 - Sequence 234077 from Patent EP1572962.
JD463404 - Sequence 444428 from Patent EP1572962.
JD383604 - Sequence 364628 from Patent EP1572962.
JD104452 - Sequence 85476 from Patent EP1572962.
JD135414 - Sequence 116438 from Patent EP1572962.
JD445713 - Sequence 426737 from Patent EP1572962.
JD373109 - Sequence 354133 from Patent EP1572962.
JD413186 - Sequence 394210 from Patent EP1572962.
JD460459 - Sequence 441483 from Patent EP1572962.
JD493889 - Sequence 474913 from Patent EP1572962.
JD161955 - Sequence 142979 from Patent EP1572962.
JD342522 - Sequence 323546 from Patent EP1572962.
JD312295 - Sequence 293319 from Patent EP1572962.
JD401136 - Sequence 382160 from Patent EP1572962.
JD056320 - Sequence 37344 from Patent EP1572962.
JD440173 - Sequence 421197 from Patent EP1572962.
JD045343 - Sequence 26367 from Patent EP1572962.
JD162177 - Sequence 143201 from Patent EP1572962.
JD365788 - Sequence 346812 from Patent EP1572962.
JD271760 - Sequence 252784 from Patent EP1572962.
JD272619 - Sequence 253643 from Patent EP1572962.
JD075142 - Sequence 56166 from Patent EP1572962.
JD098515 - Sequence 79539 from Patent EP1572962.
JD076821 - Sequence 57845 from Patent EP1572962.
JD408848 - Sequence 389872 from Patent EP1572962.
JD566611 - Sequence 547635 from Patent EP1572962.
JD140731 - Sequence 121755 from Patent EP1572962.
JD169845 - Sequence 150869 from Patent EP1572962.
JD097541 - Sequence 78565 from Patent EP1572962.
JD114752 - Sequence 95776 from Patent EP1572962.
JD550593 - Sequence 531617 from Patent EP1572962.
JD362747 - Sequence 343771 from Patent EP1572962.
JD477103 - Sequence 458127 from Patent EP1572962.
JD256650 - Sequence 237674 from Patent EP1572962.
JD102844 - Sequence 83868 from Patent EP1572962.
JD071909 - Sequence 52933 from Patent EP1572962.
JD326560 - Sequence 307584 from Patent EP1572962.
JD467768 - Sequence 448792 from Patent EP1572962.
JD480905 - Sequence 461929 from Patent EP1572962.
JD543980 - Sequence 525004 from Patent EP1572962.
JD561119 - Sequence 542143 from Patent EP1572962.
JD262192 - Sequence 243216 from Patent EP1572962.
JD087172 - Sequence 68196 from Patent EP1572962.
JD293533 - Sequence 274557 from Patent EP1572962.
JD200086 - Sequence 181110 from Patent EP1572962.
JD164814 - Sequence 145838 from Patent EP1572962.
JD479352 - Sequence 460376 from Patent EP1572962.
JD261296 - Sequence 242320 from Patent EP1572962.
JD454910 - Sequence 435934 from Patent EP1572962.
JD163985 - Sequence 145009 from Patent EP1572962.
JD425013 - Sequence 406037 from Patent EP1572962.
JD365557 - Sequence 346581 from Patent EP1572962.
JD239872 - Sequence 220896 from Patent EP1572962.
JD224476 - Sequence 205500 from Patent EP1572962.
JD140926 - Sequence 121950 from Patent EP1572962.
JD272815 - Sequence 253839 from Patent EP1572962.
JD543479 - Sequence 524503 from Patent EP1572962.
JD162211 - Sequence 143235 from Patent EP1572962.
JD162210 - Sequence 143234 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_178520, NP_848615, Q8N8V8, TM105_HUMAN
UCSC ID: uc002kad.2
RefSeq Accession: NM_178520
Protein: Q8N8V8 (aka TM105_HUMAN)
CCDS: CCDS11781.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_178520.3
exon count: 3CDS single in 3' UTR: no RNA size: 3335
ORF size: 390CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 356.00frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.