Description: Homo sapiens TEA domain family member 4 (TEAD4), transcript variant 1, mRNA. RefSeq Summary (NM_201443): This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:3,068,478-3,149,842 Size: 81,365 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr12:3,103,933-3,149,644 Size: 45,712 Coding Exon Count: 11
ID:TEAD4_HUMAN DESCRIPTION: RecName: Full=Transcriptional enhancer factor TEF-3; AltName: Full=TEA domain family member 4; Short=TEAD-4; AltName: Full=Transcription factor 13-like 1; AltName: Full=Transcription factor RTEF-1; FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. SUBUNIT: Interacts with YAP1 and WWTR1/TAZ. INTERACTION: Q9GZV5:WWTR1; NbExp=2; IntAct=EBI-747736, EBI-747743; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. SIMILARITY: Contains 1 TEA DNA-binding domain. SEQUENCE CAUTION: Sequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0001501 skeletal system development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007517 muscle organ development GO:0035329 hippo signaling GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048568 embryonic organ development
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
