Description: Homo sapiens serine/arginine-rich splicing factor 3 (SRSF3), transcript variant 1, mRNA. RefSeq Summary (NM_003017): The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]. Transcript (Including UTRs) Position: hg19 chr6:36,562,090-36,572,244 Size: 10,155 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr6:36,564,540-36,569,766 Size: 5,227 Coding Exon Count: 5
ID:SRSF3_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 3; AltName: Full=Pre-mRNA-splicing factor SRP20; AltName: Full=Splicing factor, arginine/serine-rich 3; FUNCTION: May be involved in RNA processing in relation with cellular proliferation and/or maturation. SUBUNIT: Interacts with CPSF6, RBMY1A1 and SREK1/SFRS12. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
Electrocardiography Hilma Holm et al. Nature genetics 2010, Several common variants modulate heart rate, PR interval and QRS duration., Nature genetics.
[PubMed 20062063]
Heart Function Tests Nona Sotoodehnia et al. Nature genetics 2010, Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction., Nature genetics.
[PubMed 21076409]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P84103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK312553 - Homo sapiens cDNA, FLJ92926, Homo sapiens splicing factor, arginine/serine-rich 3 (SFRS3), mRNA. BC000914 - Homo sapiens splicing factor, arginine/serine-rich 3, mRNA (cDNA clone MGC:5205 IMAGE:3049167), complete cds. BC069018 - Homo sapiens splicing factor, arginine/serine-rich 3, mRNA (cDNA clone MGC:78599 IMAGE:3507371), complete cds. GQ891426 - Homo sapiens clone HEL-S-147 epididymis secretory sperm binding protein mRNA, complete cds. AF107405 - Homo sapiens pre-mRNA splicing factor (SFRS3) mRNA, complete cds. AK310317 - Homo sapiens cDNA, FLJ17359. AB451352 - Homo sapiens SFRS3 mRNA for splicing factor arginine/serine-rich 3, partial cds, clone: FLJ08018AAAF. AB528594 - Synthetic construct DNA, clone: pF1KB3105, Homo sapiens SFRS3 gene for splicing factor, arginine/serine-rich 3, without stop codon, in Flexi system. AB451229 - Homo sapiens SFRS3 mRNA for splicing factor arginine/serine-rich 3, complete cds, clone: FLJ08018AAAN. KJ892128 - Synthetic construct Homo sapiens clone ccsbBroadEn_01522 SRSF3 gene, encodes complete protein. BT007017 - Homo sapiens splicing factor, arginine/serine-rich 3 mRNA, complete cds. L10838 - Homo sapiens SR protein family, pre-mRNA splicing factor (SRp20) mRNA, complete cds. AK091927 - Homo sapiens cDNA FLJ34608 fis, clone KIDNE2013845. AX747259 - Sequence 784 from Patent EP1308459. AK095580 - Homo sapiens cDNA FLJ38261 fis, clone FCBBF3001470. D28423 - Homo sapiens mRNA for pre-mRNA splicing factor SRp20, 5'UTR region. AK304097 - Homo sapiens cDNA FLJ52832 complete cds, highly similar to Splicing factor, arginine/serine-rich 3. JD023964 - Sequence 4988 from Patent EP1572962. JD349237 - Sequence 330261 from Patent EP1572962. JD032119 - Sequence 13143 from Patent EP1572962. LF336828 - JP 2014500723-A/144331: Polycomb-Associated Non-Coding RNAs. LF336829 - JP 2014500723-A/144332: Polycomb-Associated Non-Coding RNAs. JD313378 - Sequence 294402 from Patent EP1572962. JD316511 - Sequence 297535 from Patent EP1572962. JD297478 - Sequence 278502 from Patent EP1572962. JD524959 - Sequence 505983 from Patent EP1572962. JD249189 - Sequence 230213 from Patent EP1572962. JD348851 - Sequence 329875 from Patent EP1572962. JD358845 - Sequence 339869 from Patent EP1572962. JD268547 - Sequence 249571 from Patent EP1572962. JD069151 - Sequence 50175 from Patent EP1572962. LF336831 - JP 2014500723-A/144334: Polycomb-Associated Non-Coding RNAs. JD351385 - Sequence 332409 from Patent EP1572962. JD203045 - Sequence 184069 from Patent EP1572962. JD507807 - Sequence 488831 from Patent EP1572962. JD293565 - Sequence 274589 from Patent EP1572962. JD490575 - Sequence 471599 from Patent EP1572962. MA572405 - JP 2018138019-A/144331: Polycomb-Associated Non-Coding RNAs. MA572406 - JP 2018138019-A/144332: Polycomb-Associated Non-Coding RNAs. MA572408 - JP 2018138019-A/144334: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein P84103 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
