ID:SRRM1_HUMAN DESCRIPTION: RecName: Full=Serine/arginine repetitive matrix protein 1; AltName: Full=SR-related nuclear matrix protein of 160 kDa; Short=SRm160; AltName: Full=Ser/Arg-related nuclear matrix protein; FUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. SUBUNIT: Identified in the spliceosome C complex. Found in a pre- mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with BAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP- dependent manner. SUBCELLULAR LOCATION: Nucleus matrix. Nucleus speckle. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 1 PWI domain. SEQUENCE CAUTION: Sequence=AAC09321.1; Type=Frameshift; Positions=791; Sequence=AAP97290.1; Type=Frameshift; Positions=791;
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SRRM1 CDC HuGE Published Literature: SRRM1 Positive Disease Associations: Body Height Related Studies:
Body Height Hana Lango Allen et al. Nature 2010, Hundreds of variants clustered in genomic loci and biological pathways affect human height., Nature.
[PubMed 20881960]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IYB3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF419855 - Homo sapiens Ser/Arg-related nuclear matrix protein (SRRM1) mRNA, complete cds. BC011019 - Homo sapiens serine/arginine repetitive matrix 1, mRNA (cDNA clone IMAGE:4287134), with apparent retained intron. BC036187 - Homo sapiens serine/arginine repetitive matrix 1, mRNA (cDNA clone MGC:39488 IMAGE:4827738), complete cds. AK302498 - Homo sapiens cDNA FLJ61739 complete cds, highly similar to Serine/arginine repetitive matrix protein 1. BC017315 - Homo sapiens serine/arginine repetitive matrix 1, mRNA (cDNA clone IMAGE:3937531), partial cds. AF048977 - Homo sapiens Ser/Arg-related nuclear matrix protein (SRM160) mRNA, complete cds. KU178512 - Homo sapiens serine/arginine repetitive matrix 1 isoform 1 (SRRM1) mRNA, partial cds. KU178513 - Homo sapiens serine/arginine repetitive matrix 1 isoform 2 (SRRM1) mRNA, partial cds, alternatively spliced. AK307419 - Homo sapiens cDNA, FLJ97367. AK307568 - Homo sapiens cDNA, FLJ97516. AK293576 - Homo sapiens cDNA FLJ57710 complete cds, highly similar to Serine/arginine repetitive matrix protein 1. JD341942 - Sequence 322966 from Patent EP1572962. JD311113 - Sequence 292137 from Patent EP1572962. JD427456 - Sequence 408480 from Patent EP1572962. JD571856 - Sequence 3 from Patent WO2015030616. JD371895 - Sequence 352919 from Patent EP1572962. JD264373 - Sequence 245397 from Patent EP1572962. JD092124 - Sequence 73148 from Patent EP1572962. JD336454 - Sequence 317478 from Patent EP1572962. JD461377 - Sequence 442401 from Patent EP1572962. JD538445 - Sequence 519469 from Patent EP1572962. JD170371 - Sequence 151395 from Patent EP1572962. JD415707 - Sequence 396731 from Patent EP1572962. JD496771 - Sequence 477795 from Patent EP1572962. JD183144 - Sequence 164168 from Patent EP1572962. JD315510 - Sequence 296534 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IYB3 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
