Description: Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA. RefSeq Summary (NM_003107): This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:21,593,972-21,598,849 Size: 4,878 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr6:21,594,766-21,596,190 Size: 1,425 Coding Exon Count: 1
ID:SOX4_HUMAN DESCRIPTION: RecName: Full=Transcription factor SOX-4; FUNCTION: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SUBUNIT: Interacts with UBE2I. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis, brain, and heart. SIMILARITY: Contains 1 HMG box DNA-binding domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SOX4ID42358ch6p22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q06945
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.