Human Gene SNX24 (uc003ktf.2)
  Description: Homo sapiens sorting nexin 24 (SNX24), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:122,181,160-122,337,836 Size: 156,677 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr5:122,181,329-122,337,737 Size: 156,409 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:122,181,160-122,337,836)mRNA (may differ from genome)Protein (159 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SNX24
CDC HuGE Published Literature: SNX24
Positive Disease Associations: Body Mass Index
Related Studies:
  1. Body Mass Index
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.80 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 191.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.30169-0.676 Picture PostScript Text
3' UTR -19.5499-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00787 - PX domain

SCOP Domains:
64268 - PX domain

ModBase Predicted Comparative 3D Structure on Q9Y343-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC010886 - Homo sapiens sorting nexin 24, mRNA (cDNA clone MGC:745 IMAGE:3538426), complete cds.
BC069012 - Homo sapiens sorting nexin 24, mRNA (cDNA clone MGC:78539 IMAGE:4585781), complete cds.
AF139461 - Homo sapiens hypothetical protein SBBI31 mRNA, complete cds.
AY358098 - Homo sapiens clone DNA66477 SBBI31 (UNQ654) mRNA, complete cds.
CU679837 - Synthetic construct Homo sapiens gateway clone IMAGE:100020747 5' read SNX24 mRNA.
CU686699 - Synthetic construct Homo sapiens gateway clone IMAGE:100023051 5' read SNX24 mRNA.
HQ448039 - Synthetic construct Homo sapiens clone IMAGE:100071414; CCSB005986_03 sorting nexing 24 (SNX24) gene, encodes complete protein.
KJ893652 - Synthetic construct Homo sapiens clone ccsbBroadEn_03046 SNX24 gene, encodes complete protein.
KJ902494 - Synthetic construct Homo sapiens clone ccsbBroadEn_11888 SNX24 gene, encodes complete protein.
AY044655 - Homo sapiens sorting nexin SNX24 (SNX24) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AY358098, NM_014035, NP_054754, Q9Y343-2, SBBI31, UNQ654/PRO1284
UCSC ID: uc003ktf.2
RefSeq Accession: NM_014035
Protein: Q9Y343-2, splice isoform of Q9Y343

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY358098.1
exon count: 6CDS single in 3' UTR: no RNA size: 597
ORF size: 480CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1160.00frame shift in genome: no % Coverage: 98.32
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 61# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.