Description: Homo sapiens ring finger protein 40, E3 ubiquitin protein ligase (RNF40), transcript variant 1, mRNA. RefSeq Summary (NM_014771): The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. Transcript (Including UTRs) Position: hg19 chr16:30,772,933-30,787,628 Size: 14,696 Total Exon Count: 20 Strand: + Coding Region Position: hg19 chr16:30,773,867-30,785,435 Size: 11,569 Coding Exon Count: 19
ID:BRE1B_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase BRE1B; Short=BRE1-B; EC=6.3.2.-; AltName: Full=95 kDa retinoblastoma-associated protein; Short=RBP95; AltName: Full=RING finger protein 40; FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC. INTERACTION: P06400:RB1; NbExp=3; IntAct=EBI-744408, EBI-491274; Q5VTR2:RNF20; NbExp=10; IntAct=EBI-744408, EBI-2372238; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. SIMILARITY: Belongs to the BRE1 family. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA31636.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAE45869.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75150
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006325 chromatin organization GO:0006511 ubiquitin-dependent protein catabolic process GO:0010390 histone monoubiquitination GO:0016567 protein ubiquitination GO:0033523 histone H2B ubiquitination GO:0043434 response to peptide hormone GO:1900364 negative regulation of mRNA polyadenylation GO:1901800 positive regulation of proteasomal protein catabolic process GO:1902916 positive regulation of protein polyubiquitination GO:2001168 positive regulation of histone H2B ubiquitination GO:0007346 regulation of mitotic cell cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
