ID:RN187_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF187; EC=6.3.2.-; AltName: Full=RING domain AP1 coactivator 1; Short=RACO-1; AltName: Full=RING finger protein 187; FUNCTION: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with JUN, independently of JUN phosphorylation. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus. DOMAIN: The RING-type zinc finger domain is required for E3 ligase activity. PTM: Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'- linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'- linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded. SIMILARITY: Contains 1 RING-type zinc finger. CAUTION: This sequence initiates at a CTG codon (PubMed:20852630). SEQUENCE CAUTION: Sequence=AAH12758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH12758.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAI23328.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TA31
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008284 positive regulation of cell proliferation GO:0016567 protein ubiquitination GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045893 positive regulation of transcription, DNA-templated GO:0051865 protein autoubiquitination GO:0070936 protein K48-linked ubiquitination
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
