Human Gene REEP4 (uc003xau.1)
  Description: Homo sapiens receptor accessory protein 4 (REEP4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:21,995,533-21,999,448 Size: 3,916 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr8:21,996,000-21,998,995 Size: 2,996 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:21,995,533-21,999,448)mRNA (may differ from genome)Protein (257 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: REEP4_HUMAN
DESCRIPTION: RecName: Full=Receptor expression-enhancing protein 4;
FUNCTION: May enhance the cell surface expression of odorant receptors (By similarity).
SUBUNIT: Interacts with odorant receptor proteins (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the DP1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.71 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 673.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -223.30453-0.493 Picture PostScript Text
3' UTR -166.30467-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004345 - TB2_DP1_HVA22

Pfam Domains:
PF03134 - TB2/DP1, HVA22 family

ModBase Predicted Comparative 3D Structure on Q9H6H4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008017 microtubule binding

Biological Process:
GO:0006998 nuclear envelope organization
GO:0007049 cell cycle
GO:0007084 mitotic nuclear envelope reassembly
GO:0051301 cell division

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF210148 - JP 2014500723-A/17651: Polycomb-Associated Non-Coding RNAs.
AK025930 - Homo sapiens cDNA: FLJ22277 fis, clone HRC03740.
AF218014 - Homo sapiens clone PP432 unknown mRNA.
BC050622 - Homo sapiens receptor accessory protein 4, mRNA (cDNA clone MGC:60090 IMAGE:6504298), complete cds.
BC013048 - Homo sapiens receptor accessory protein 4, mRNA (cDNA clone MGC:9377 IMAGE:3863838), complete cds.
LF335126 - JP 2014500723-A/142629: Polycomb-Associated Non-Coding RNAs.
JD058159 - Sequence 39183 from Patent EP1572962.
AK172846 - Homo sapiens cDNA FLJ24007 fis, clone KAT02841.
AK025899 - Homo sapiens cDNA: FLJ22246 fis, clone HRC02637.
JD361953 - Sequence 342977 from Patent EP1572962.
JD076691 - Sequence 57715 from Patent EP1572962.
JD364827 - Sequence 345851 from Patent EP1572962.
JD477349 - Sequence 458373 from Patent EP1572962.
JD526803 - Sequence 507827 from Patent EP1572962.
JD257736 - Sequence 238760 from Patent EP1572962.
AY562242 - Homo sapiens receptor expression enhancing protein 4 (REEP4) mRNA, complete cds.
JF432791 - Synthetic construct Homo sapiens clone IMAGE:100074038 receptor accessory protein 4 (REEP4) gene, encodes complete protein.
KJ894819 - Synthetic construct Homo sapiens clone ccsbBroadEn_04213 REEP4 gene, encodes complete protein.
CR457353 - Homo sapiens full open reading frame cDNA clone RZPDo834C0810D for gene FLJ22246, hypothetical protein FLJ22246; complete cds, incl. stopcodon.
LF335125 - JP 2014500723-A/142628: Polycomb-Associated Non-Coding RNAs.
LF335124 - JP 2014500723-A/142627: Polycomb-Associated Non-Coding RNAs.
AK302352 - Homo sapiens cDNA FLJ56749 complete cds, highly similar to Receptor expression-enhancing protein 4.
LF335121 - JP 2014500723-A/142624: Polycomb-Associated Non-Coding RNAs.
JD025097 - Sequence 6121 from Patent EP1572962.
JD227381 - Sequence 208405 from Patent EP1572962.
JD439129 - Sequence 420153 from Patent EP1572962.
JD336600 - Sequence 317624 from Patent EP1572962.
MA445725 - JP 2018138019-A/17651: Polycomb-Associated Non-Coding RNAs.
MA570703 - JP 2018138019-A/142629: Polycomb-Associated Non-Coding RNAs.
MA570702 - JP 2018138019-A/142628: Polycomb-Associated Non-Coding RNAs.
MA570701 - JP 2018138019-A/142627: Polycomb-Associated Non-Coding RNAs.
MA570698 - JP 2018138019-A/142624: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: C8orf20, D3DSQ9, NM_025232, NP_079508, PP432, Q86VL1, Q9H6H4, Q9H6I5, Q9HBP4, REEP4_HUMAN
UCSC ID: uc003xau.1
RefSeq Accession: NM_025232
Protein: Q9H6H4 (aka REEP4_HUMAN)
CCDS: CCDS6024.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_025232.2
exon count: 8CDS single in 3' UTR: no RNA size: 1731
ORF size: 774CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1748.00frame shift in genome: no % Coverage: 97.86
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.