Description: Homo sapiens protein phosphatase 2, regulatory subunit B'', beta (PPP2R3B), mRNA. RefSeq Summary (NM_013239): Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chrX:294,668-347,690 Size: 53,023 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chrX:295,102-347,426 Size: 52,325 Coding Exon Count: 13
ID:P2R3B_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; AltName: Full=PP2A subunit B isoform PR48; AltName: Full=Protein phosphatase 2A 48 kDa regulatory subunit; FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. SIMILARITY: Contains 1 EF-hand domain. SEQUENCE CAUTION: Sequence=AAD38515.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5P8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity GO:0046872 metal ion binding
Biological Process: GO:0006470 protein dephosphorylation GO:0007050 cell cycle arrest GO:0043666 regulation of phosphoprotein phosphatase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
