Human Gene PNMA2 (uc003xez.2)
  Description: Homo sapiens paraneoplastic Ma antigen 2 (PNMA2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:26,362,196-26,371,483 Size: 9,288 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr8:26,365,177-26,366,271 Size: 1,095 Coding Exon Count: 1 

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CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:26,362,196-26,371,483)mRNA (may differ from genome)Protein (364 aa)
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-  Comments and Description Text from UniProtKB
  ID: PNMA2_HUMAN
DESCRIPTION: RecName: Full=Paraneoplastic antigen Ma2; AltName: Full=40 kDa neuronal protein; AltName: Full=Onconeuronal antigen Ma2; AltName: Full=Paraneoplastic neuronal antigen MM2;
INTERACTION: P16333:NCK1; NbExp=2; IntAct=EBI-302355, EBI-389883;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Brain specific. In some patients suffering from cancers, it is also specifically expressed by the testicular tumor cells.
MISCELLANEOUS: Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.
SIMILARITY: Belongs to the PNMA family.
SEQUENCE CAUTION: Sequence=BAA74906.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PNMA2
CDC HuGE Published Literature: PNMA2
Positive Disease Associations: Erythrocyte Count , Hemoglobins
Related Studies:
  1. Erythrocyte Count
    , , . [PubMed 0]
  2. Hemoglobins
    , , . [PubMed 0]
  3. Hemoglobins
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: PNMA2
Diseases sorted by gene-association score: limbic encephalitis (2), oculomotor nerve paralysis (2), third cranial nerve disease (2), agraphia (2), lateral medullary syndrome (1), peliosis hepatis (1), branch retinal artery occlusion (1), testis seminoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.72 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 38.85 RPKM