Description: Homo sapiens plakophilin 3 (PKP3), mRNA. RefSeq Summary (NM_007183): This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]. Transcript (Including UTRs) Position: hg19 chr11:394,217-404,908 Size: 10,692 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr11:394,293-404,569 Size: 10,277 Coding Exon Count: 13
ID:PKP3_HUMAN DESCRIPTION: RecName: Full=Plakophilin-3; FUNCTION: May play a role in junctional plaques. SUBCELLULAR LOCATION: Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. TISSUE SPECIFICITY: Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. SIMILARITY: Belongs to the beta-catenin family. SIMILARITY: Contains 8 ARM repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y446
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.