Description: Homo sapiens PET100 homolog (S. cerevisiae) (PET100), transcript variant 1, mRNA. RefSeq Summary (NM_001171155): Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by this gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Transcript (Including UTRs) Position: hg19 chr19:7,694,671-7,696,510 Size: 1,840 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr19:7,694,720-7,696,442 Size: 1,723 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0DJ07
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0051082 unfolded protein binding
Biological Process: GO:0033617 mitochondrial respiratory chain complex IV assembly
Cellular Component: GO:0005739 mitochondrion GO:0016020 membrane GO:0016021 integral component of membrane GO:0031305 integral component of mitochondrial inner membrane