Description: Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA. RefSeq Summary (NM_002563): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr3:152,552,736-152,555,843 Size: 3,108 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chr3:152,553,572-152,554,693 Size: 1,122 Coding Exon Count: 1
ID:P2RY1_HUMAN DESCRIPTION: RecName: Full=P2Y purinoceptor 1; Short=P2Y1; AltName: Full=ATP receptor; AltName: Full=Purinergic receptor; FUNCTION: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. INDUCTION: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
hematology indices Hetherington, S. L. et al. 2004, Dimorphism in the P2Y1 ADP Receptor Gene Is Associated With Increased Platelet Activation Response to ADP, Arteriosclerosis, thrombosis, and vascular biology. 2005 Jan;25(1):252-7.
[PubMed 15514209]
A common genetic variant at the P2Y1 locus is associated with platelet reactivity to ADP. This genotype effect partly explains the interindividual variation in platelet response to ADP and may have clinical implications with regard to thrombotic risk.
Leukemia, Lymphocytic, Chronic, B-Cell Rachel Wade et al. Haematologica 2011, Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial., Haematologica.
[PubMed 21659360]
Our findings provide evidence that genetic variation is a determinant of progression-free survival of patients with chronic lymphocytic leukemia. Specific associations warrant further analyses.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47900
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
