Description: Homo sapiens mitochondrial calcium uptake 1 (MICU1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. RefSeq Summary (NM_006077): This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]. Transcript (Including UTRs) Position: hg19 chr10:74,127,084-74,385,949 Size: 258,866 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr10:74,127,953-74,326,551 Size: 198,599 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF13202 - EF hand PF13405 - EF-hand domain PF13833 - EF-hand domain pair
ModBase Predicted Comparative 3D Structure on Q9BPX6-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK022697 - Homo sapiens cDNA FLJ12635 fis, clone NT2RM4001865, highly similar to Homo sapiens mRNA for atopy related autoantigen CALC. BC016641 - Homo sapiens calcium binding atopy-related autoantigen 1, mRNA (cDNA clone MGC:17962 IMAGE:3919114), complete cds. AL117423 - Homo sapiens mRNA; cDNA DKFZp564C246 (from clone DKFZp564C246). AK225298 - Homo sapiens mRNA for calcium binding atopy-related autoantigen 1 variant, clone: HEP03393. BC004190 - Homo sapiens calcium binding atopy-related autoantigen 1, mRNA (cDNA clone MGC:2891 IMAGE:3009677), complete cds. BC004216 - Homo sapiens calcium binding atopy-related autoantigen 1, mRNA (cDNA clone MGC:4521 IMAGE:3009677), complete cds. Y17711 - Homo sapiens mRNA for atopy related autoantigen CALC. AK225695 - Homo sapiens mRNA for calcium binding atopy-related autoantigen 1 variant, clone: SYN04411. AK296086 - Homo sapiens cDNA FLJ54794 complete cds, highly similar to Homo sapiens calcium binding atopy-related autoantigen 1 (CBARA1), mRNA. AK023318 - Homo sapiens cDNA FLJ13256 fis, clone OVARC1000834, highly similar to Homo sapiens calcium binding atopy-related autoantigen 1 (CBARA1), mRNA. AK298347 - Homo sapiens cDNA FLJ54801 complete cds, highly similar to Homo sapiens calcium binding atopy-related autoantigen 1 (CBARA1), mRNA. DQ891087 - Synthetic construct clone IMAGE:100003717; FLH169226.01X; RZPDo839H1094D calcium binding atopy-related autoantigen 1 (CBARA1) gene, encodes complete protein. KJ893016 - Synthetic construct Homo sapiens clone ccsbBroadEn_02410 MICU1 gene, encodes complete protein. EU176543 - Synthetic construct Homo sapiens clone IMAGE:100011372; FLH169225.01L; RZPDo839D10253D calcium binding atopy-related autoantigen 1 (CBARA1) gene, encodes complete protein. CU677655 - Synthetic construct Homo sapiens gateway clone IMAGE:100019577 5' read CBARA1 mRNA. JD311560 - Sequence 292584 from Patent EP1572962. JD174143 - Sequence 155167 from Patent EP1572962. JD465107 - Sequence 446131 from Patent EP1572962. JD170314 - Sequence 151338 from Patent EP1572962. JD076090 - Sequence 57114 from Patent EP1572962. JD088706 - Sequence 69730 from Patent EP1572962. JD087921 - Sequence 68945 from Patent EP1572962. JD350031 - Sequence 331055 from Patent EP1572962. JD251208 - Sequence 232232 from Patent EP1572962. JD288062 - Sequence 269086 from Patent EP1572962. JD226508 - Sequence 207532 from Patent EP1572962. JD527735 - Sequence 508759 from Patent EP1572962. JD163974 - Sequence 144998 from Patent EP1572962. JD215112 - Sequence 196136 from Patent EP1572962. JD096253 - Sequence 77277 from Patent EP1572962. JD563192 - Sequence 544216 from Patent EP1572962. JD264431 - Sequence 245455 from Patent EP1572962. JD278304 - Sequence 259328 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BPX6 (Reactome details) participates in the following event(s):
R-HSA-8953461 SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex R-HSA-8949178 MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix R-HSA-8949664 Processing of SMDT1 R-HSA-8949215 Mitochondrial calcium ion transport R-HSA-382551 Transport of small molecules