Description: Homo sapiens Mdm1 nuclear protein homolog (mouse) (MDM1), transcript variant 1, mRNA. RefSeq Summary (NM_017440): This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]. Transcript (Including UTRs) Position: hg19 chr12:68,688,346-68,726,161 Size: 37,816 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr12:68,689,034-68,726,025 Size: 36,992 Coding Exon Count: 14
Attention Deficit Disorder with Hyperactivity , , .
[PubMed 0]
Bipolar Disorder Tiffany A Greenwood et al. Biological psychiatry 2012, Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci., Biological psychiatry.
[PubMed 22365631]
These results suggest that aspects of temperament might define subtypes of BD that are more clinically and genetically homogenous, which might aid in the identification of predisposing genetic variants.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TC05
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
