Description: Homo sapiens lactate dehydrogenase A (LDHA), transcript variant 3, mRNA. RefSeq Summary (NM_001165414): The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]. Transcript (Including UTRs) Position: hg19 chr11:18,417,813-18,429,765 Size: 11,953 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr11:18,418,095-18,428,828 Size: 10,734 Coding Exon Count: 8
panic disorder Philibert, R. A. et al. 2003, Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder., American journal of medical genetics Part B, Neuropsychiatric genetics. 2003 Feb;117(1):7-Nov.
[PubMed 12555229]
Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge.
Serum Amyloid A Protein Carola Marzi et al. PLoS genetics 2010, Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A., PLoS genetics.
[PubMed 21124955]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P00338-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
